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Cefovecin

Cefovecin structure

CAS No:
234096-34-5
Formula:
C17H19N5O6S2
Chemical Name:
Cefovecin
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[(2S)-tetrahydro-2-furanyl]-,(6R,7R)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[(2S)-tetrahydro-2-furanyl]-,(6R,7R)-;(6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[(2S)-tetrahydro-2-furanyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;Cefovecin;Convenia
Categories:
Active Pharmaceutical Ingredients > Other Chemical Drugs

Description

Cefovecin is a cephalosporin antibiotic used for the treatment of skin infections in cats and dogs. It is the first single-dose injectable antibiotic for dogs and cats that assures owner compliance with dosing for the animal. It is used for the treatment of skin infections caused by Pasturella multocida in cats, and Staphylococcus intermedius/S. canis in dogs. The advantage of using injectable antibiotics is not missing a dose that can allow partially resistant microbes to recover during missed doses. However, these injectable agents can present long-lasting subtherapeutic concentrations after the resolution of infection. The presence of low concentrations of antibiotics is related to the development of microbial resistance.|Cefovecin is a semisynthetic, broad-spectrum, third-generation cephalosporin with antibacterial activity. Cefovecin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Cefovecin Basic Attributes

Molecular Weight：

453.49300

Exact Mass：

453.49

UNII：

0D1OL46ZIE

DSSTox ID：

DTXSID00177963

NCI Thesaurus Code：

C76035

ATC Code：

QJ01DD91

Characteristics

PSA：

214.20000

XLogP3：

0.70170

Density：

1.859g/cm3

Refractive Index：

1.832

Drug Information

Drug Indication：

DogsFor the treatment of skin and soft-tissue infections including pyoderma, wounds and abscesses associated with Staphylococcus pseudintermedius, β-haemolytic streptococci, Escherichia coli and / or Pasteurella multocida.For the treatment of urinary-tract infections associated with Escherichia coli and / or Proteus spp.As adjunctive treatment to mechanical or surgical periodontal therapy in the treatment of severe infections of the gingiva and periodontal tissues associated with Porphyromonas spp. and Prevotella spp.CatsFor the treatment of skin and soft-tissue abscesses and wounds associated with Pasteurella multocida, Usobacterium spp., Bacteroides spp., Prevotella oralis, β-haemolytic streptococci and / or Staphylococcus pseudintermedius.For the treatment of urinary-tract infections associated with Escherichia coli.

MeSH Entry Terms：

cefovecin

Cefovecin Use and Manufacturing

Use Classification：

Veterinary drugs -> Convenia -> EMA Drug Category|Antibacterials for systemic use -> Veterinary pharmacotherapeutic group

Computed Properties

Molecular Weight:453.5
XLogP3:-0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:6
Exact Mass:453.07767569
Monoisotopic Mass:453.07767569
Topological Polar Surface Area:210
Heavy Atom Count:30
Complexity:821
Defined Atom Stereocenter Count:3
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes