methyl 2-[[4-butyl-2-methyl-6-oxo-5-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-1-yl]methyl]thiophene-3-carboxylate
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![methyl 2-[[4-butyl-2-methyl-6-oxo-5-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-1-yl]methyl]thiophene-3-carboxylate structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/684a9e9e8d2a4135acdb9b6860da5690.png "methyl 2-[[4-butyl-2-methyl-6-oxo-5-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-1-yl]methyl]thiophene-3-carboxylate")
methyl 2-[[4-butyl-2-methyl-6-oxo-5-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-1-yl]methyl]thiophene-3-carboxylate
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CAS No:
148564-47-0
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Formula:
C30H30N6O3S
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Chemical Name:
methyl 2-[[4-butyl-2-methyl-6-oxo-5-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-1-yl]methyl]thiophene-3-carboxylate
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Synonyms:
methyl 2-((4-butyl-2-methyl-6-oxo-5-((2'-(1H-tetrazol-5-yl)-(1,1'-biphenyl)-4-yl)methyl)-1(6H)-pyrimidinyl)methyl)-3-thiophencarboxylate; methyl 2-<<4-butyl-2-methyl-6-oxo-5-<<2'-(1H-tetrazol-5-yl)<1,1'-biphenyl>-4-yl>methyl>-1(6H)-pyrimidinyl>methyl>-3-thiophenecarboxylate; UNII-8UAL5421CL; Milfasartan [INN]; methyl 2-<(4-butyl-2-methyl-6-oxo-5-<4-<2-(1H-tetrazol-5-yl)phenyl>benzyl>-1H-pyrimidin-1-yl)methyl>-3-thiophenecarboxylate; Methyl 2-((4-butyl-2-methyl-6-oxo-5-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-1(6H)-pyrimidinyl)methyl)-3-thiophenecarboxylate; 2-[(4-butyl-2-methyl-6-oxo-5-{[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl}-6H-pyrimidin-1-yl)methyl]-3-thiophenecarboxylic acid methyl ester; Milfasartan; 4-butyl-1-[(3-methoxycarbonylthien-2-yl)-methyl]-2-methyl-5-[[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]methyl]-pyrimidin-6-one;Expand
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CAS No:
Description
Milfasartan is a nonpeptide angiotensin II receptor antagonist with antihypertensive activity. Milfasartan selectively competes with angiotensin II for the binding of the angiotensin II (AT1) receptor subtype 1 in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction resulting in vascular dilatation. In addition, the antagonistic effect on AT1 in the adrenal gland, prevents angiotensin II-induced stimulation of aldosterone synthesis and secretion by the adrenal cortex. This blocks the effects of aldosterone leading to an increase in sodium excretion and water and eventually a reduction in plasma volume and blood pressure.
methyl 2-[[4-butyl-2-methyl-6-oxo-5-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-1-yl]methyl]thiophene-3-carboxylate Basic Attributes
554.66300
554.21001001
8UAL5421CL
DTXSID70164007
C66152
Computed Properties
Molecular Weight:554.7
XLogP3:5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:11
Exact Mass:554.21001001
Monoisotopic Mass:554.21001001
Topological Polar Surface Area:142
Heavy Atom Count:40
Complexity:965
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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