methyl 6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
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methyl 6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
structure -
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CAS No:
1263-58-7
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Formula:
C33H40N2O9
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Chemical Name:
methyl 6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
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Synonyms:
Raunervil;Raupasil;Rausedil;Rausedyl;Reserpine;Serpasil;Serpivite;V Serp;V-Serp;Isoreserpin;Salutensin;Diupres;Diutensen-R;Broserpine;Klimanosid;Reserpidefe;Reserpinum;Sedaraupin;Sedaraupina;Sederaupin;Serpaneurona;Serpentina;Tefaserpina;Temposerpine;Tenserpinie;Tepserpine;Carpacil;Deserpine;Eberpine;Eberspine;Gilucard;Raudixin;Recipin;Resaltex;Resedril;Reserfia;Reserpka;Reserpur;Resiatric;Residine;Resocalm;Resperin;Resperine;Rezerpin;Rivased;Rolserp;Roxynoid;Sandron;Sedserp;Serfolia;Serolfia;Serpaloid;Serpasol;Serpazil;Serpazol;Serpedin;Serpena;Serpentil;Serpentin;Serpicon;Serpiloid;Serpine;Serpipur;Serpogen;Serpoid;Serpone;Serpyrit;Sertabs;Sertens;Sertensin;Sertina;Triserpin;Unilord;1263-58-7;Serfin;Serpen;Serpil;Yohimban-16-carboxylic acid, 11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester, (3.beta.,16.beta.,17.alpha.,18.beta.,20.alpha.)-;Roxel;Serpasil premix;Tempo-Reserpina;Rese-lar;Reser-ar;Vio-Serpine;SK-Reserpine;l -Carpserp;Renese R;T-Serp;V-Serp;Serp-AFD;Usaf cb-27;R-e-s;3,8-dimethoxy-4-(methoxycarbonyl)-1,2,3,4,5,11,14,14a,4a,5a-decahydrobenzo[3,4 -g]indolo[2,3-a]quinolizin-2-yl 3,4,5-trimethoxybenzoate;6,18-dimethoxy-17-[oxo-(3,4,5-trimethoxyphenyl)methoxy]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylic acid methyl ester;methyl 6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate;Serpine (pharmaceutical);Rcra waste number U200;Brinderdin;Butiserpine;Cardioserpin;Gamaserpin;Hypertensan;Mepireserpate;Neoslowten;Orthoserpina;Perskleran;Pressimedin;Resercrine;Tensionorme;Transerpin;Adelfan;Adelphin;Alkaserp;Ascoserp;Banisil;Briserine;C33H40N2O9;Darebon;Ebserpine;Elfanex;Hexaplin;Idoserp;Modenol;Rauloycin;Rauserpin;Rauvilid;Resedin;Resersana;Reserutin;Resomine;Salupres;Sarpagen;Seominal;Serpatone;Serpilum;Serpresan;Supergan;Tensanyl;Tenserlix;Tensional;Terbolan;Tylandril;Veriloid;Abesta;Abicol;Hypertane forte;Neo-antitersol;NSC80138;Rauserpen-alk;Seda-salurepin;
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CAS No:
Description
6,18-dimethoxy-17-[oxo-(3,4,5-trimethoxyphenyl)methoxy]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylic acid methyl ester is a yohimban alkaloid.|An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
methyl 6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate Basic Attributes
608.7 g/mol
608.27338086 g/mol
169414|80138
Drug Information
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)|Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)
Raunervil
methyl 6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate Use and Manufacturing
Yohimban-16-carboxylic acid, 11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester, (3.beta.,16.beta.,17.alpha.,18.beta.,20.alpha.)-: ACTIVE|S - indicates a substance that is identified in a final Significant New Use Rule.
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:608.7
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:10
Exact Mass:608.27338086
Monoisotopic Mass:608.27338086
Topological Polar Surface Area:118
Heavy Atom Count:44
Complexity:1000
Undefined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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