4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine
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![4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/dae08b696e664430b2683db93202c00e.png "4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine")
4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine
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CAS No:
66000-40-6
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Formula:
C10H10F3N3
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Chemical Name:
4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine
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Synonyms:
1H-Pyrazol-3-amine,4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-;4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine;BW 755C;3-Amino-1-[3-(trifluoromethyl)phenyl]pyrazoline;Compound BW 755C;3-Amino-1-[m-(trifluoromethyl)phenyl]-2-pyrazoline;3-Amino-1-[3-(trifluoromethyl)phenyl]-2-pyrazoline;1-(3-Trifluoromethylphenyl)-4,5-dihydro-1H-pyrazol-3-amine;1-[3-(Trifluoromethyl)phenyl]-4,5-dihydro-1H-pyrazol-3-amine;2-[3-(Trifluoromethyl)phenyl]-3,4-dihydropyrazol-5-amine;86403-25-0;86403-24-9
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CAS No:
Description
A dual inhibitor of both cyclooxygenase and lipoxygenase pathways. It exerts an anti-inflammatory effect by inhibiting the formation of prostaglandins and leukotrienes. The drug also enhances pulmonary hypoxic vasoconstriction and has a protective effect after myocardial ischemia.
4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine Basic Attributes
229.20 g/mol
229.20
266-051-8
6V6JF56BXO
DTXSID30216213
Drug Information
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)|Compounds that bind to and inhibit that enzymatic activity of LIPOXYGENASES. Included under this category are inhibitors that are specific for lipoxygenase subtypes and act to reduce the production of LEUKOTRIENES. (See all compounds classified as Lipoxygenase Inhibitors.)
4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
Computed Properties
Molecular Weight:229.20
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:229.08268182
Monoisotopic Mass:229.08268182
Topological Polar Surface Area:41.6
Heavy Atom Count:16
Complexity:288
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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