[131I]-m-Iodobenzylguanidine
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![[131I]-m-Iodobenzylguanidine structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/7b0f692f789645f0b4e76870ec1a17eb.png "[131I]-m-Iodobenzylguanidine")
[131I]-m-Iodobenzylguanidine
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CAS No:
77679-27-7
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Formula:
C8H10IN3
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Chemical Name:
[131I]-m-Iodobenzylguanidine
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Synonyms:
Guanidine,[[3-(iodo-131I)phenyl]methyl]-;[[3-(Iodo-131I)phenyl]methyl]guanidine;[131I]-m-Iodobenzylguanidine;Iobenguane (131I);m-[131I]Iodobenzylguanidine;m-Iodobenzylguanidine-131I;Iobenguane I 131;[131I]-m-Iodobenzylguanidine;131I-MIBG;Azedra;Ultratrace Iobenguane 131I;1810732-11-6
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CAS No:
Description
Iobenguane (131I) is an organoiodine compound.|Iobenguane i-131 is a Radioactive Diagnostic Agent. The mechanism of action of iobenguane i-131 is as a Radiopharmaceutical Activity.|Iobenguane I-131 is an I 131 radioiodinated synthetic analogue of the neurotransmitter norepinephrine. Iobenguane localizes to adrenergic tissue and, in radioiodinated forms, may be used to image or eradicate tumor cells that take up and metabolize norepinephrine.|A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.
[131I]-m-Iodobenzylguanidine Basic Attributes
279.09 g/mol
278.993599 g/mol
Q461L7AK4R
DTXSID30228311
C970
V - Various
Drug Information
Drug: Iobenguanei131
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161) (See all compounds classified as Radiopharmaceuticals.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
(3-Iodo-(131I)benzyl)guanidine
[131I]-m-Iodobenzylguanidine Use and Manufacturing
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:279.09
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:278.993599
Monoisotopic Mass:278.993599
Topological Polar Surface Area:64.4
Heavy Atom Count:12
Complexity:166
Isotope Atom Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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