CPHPC
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CPHPC
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CAS No:
224624-80-0
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Formula:
C16H24N2O6
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Chemical Name:
CPHPC
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Synonyms:
D-Proline,1,1′-(1,6-dioxo-1,6-hexanediyl)bis-;1,1′-(1,6-Dioxo-1,6-hexanediyl)bis[D-proline];Ro 63-8695;CPHPC;Miridesap;GSK 2315698;1,1′-hexanedioydi-D-proline
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CAS No:
Description
Miridesap has been used in trials studying the prevention of HIV.|Miridesap is a small molecule compound that depletes serum amyloid P component (SAP), with potential anti-amyloid activity. Upon injection, miridesap binds to circulating SAP, forming complexes that are rapidly cleared in the liver. SAP bound to amyloid deposits is in equilibrium with plasma SAP, and depletion of the latter should lead to the eventual removal of SAP from amyloid deposits as well. SAP is a universal component of amyloid deposits and contributes to the pathogenesis of amyloidosis.
Safety Information
|Danger|H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Treatment of transthyretin amyloidosis (ATTR)|Treatment of systemic light chain amyloidosis
(2R,2'R)-1,1'-(1,6-Dioxo-1,6-hexanediyl)di(2-pyrrolidinecarboxylic acid)
Computed Properties
Molecular Weight:340.37
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:340.16343649
Monoisotopic Mass:340.16343649
Topological Polar Surface Area:115
Heavy Atom Count:24
Complexity:475
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes