 Home > Encyclopedia > Ganirelix

Ganirelix

Ganirelix structure

CAS No:
129311-55-3
Formula:
C80H113ClN18O13
Chemical Name:
Ganirelix
Synonyms:
N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylaMino)Methylene]-D-lysyl-L-leucyl-N6-[bis(ethylaMino)Methylene]-L-lysyl-L-prolyl-;Ganirelix acetate salt;N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylamino)methylene]-D-lysyl-L-leucyl-N6-[bis(ethylamino)methylene]-L-lysyl-L-prolyl-D-alaninamide diacetate;Ganirelix USP/EP/BP;Ganirelix Diacetate salt
Categories:
Organic Chemistry > Nitrogen Compounds

Description

Ganirelix acetate was introduced in Germany as prefilled syringes for subcutaneous injections that inhibit premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation. This decapeptide analog of luteinizing hormonereleasing hormone (LH-RH) is the second third-generation LH-RH antagonist to be launched after citrorelix (Asta Medica). This highly bioavailable compound immediately blocks the endogenous release by the pituitary gland of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), the hormone that induces ovulation. After discontinuation of the treatment, the pituitary-gonadal function is rapidly recovered due to its short-half life. As a consequence, ganirelix at daily doses of 0.25 mg S.C. efficiently prevented LH surges during clinical trials in infertile women under controlled ovarian hyperstimulation with recombinant FSH before in vitro fertilization or similar reproductive techniques. Unlike first and second-generation gonadotropin-releasing hormone antagonists, ganirelix has minimal histamine-releasing effects thus avoiding the formation of edema of the face and extremities. Ganirelix is very resistant to hydrolysis and, in contrast to the already established cetrorelix, has good water solubility.

Ganirelix Basic Attributes

Molecular Weight：

1570.31902

Color/Form：

white

Characteristics

PKA：

4.2 (3-pyridinylalanine); 9.8 (tyrosine)

Critical Temperature & Pressure：

-20°C

Safety Information

wgk germany：

hazard class code：

Hazard Statements：

36/37/38

Ganirelix Use and Manufacturing

Decapeptide LH-RH antagonist. Used in treatment of infertility.

Recommended Suppliers of Ganirelix

Jinshu Peptide Co.,Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of peptone

Ganirelix factory direct high quality white raw powder wholwsale

CAS No.: 129311-55-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Hangzhou Fullas Pharmatech Co.,Ltd. Contact Supplier

CN
1 YR

Business licensed

Distributor Supplier of GLP-1,Tirzepatide,Retatrutide,MOTS-c,MOTS-c

Ganirelix

CAS No.: 129311-55-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Hybio Pharmaceutical Co.,Ltd (Wuhan) Contact Supplier

CN
2 YRS

Business licensed Certified factory

Manufactory Supplier of Peptide,Polypeptides

Ganirelix

CAS No.: 129311-55-3

Inquiry