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Dexpanthenol

Dexpanthenol structure

CAS No:
81-13-0
Formula:
C9H19NO4
Chemical Name:
Dexpanthenol
Synonyms:
4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-(theta)-butanamid;4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-d-(+)-butyramid;Alcopan-250;Bepanthen;Bepanthene;Bepantol;Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-;Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (R)-
Categories:
Food Additives > Other Food Additives

Description

Dexpanthenol belongs to a derivative of pantothenic acid (vitamin B5). It can penetrate the skin and mucous membrane to be quickly oxidized to pantothenic acid. The later one is extremely hygroscopic and binds water effectively. Therefore, Dexpanthenol can be used as a moisturizer. It is added to pharmaceutical and cosmetic products to relieve itching and improve wound healing. In ointments, it can be used for the treatment of sunburns, mild burns, minor skin injuries and disorders. It is also immediately applied after major abdominal surgery to minimize the possibility of paralytic ileus. In addition, it can also be supplemented into the commercial shampoos and hair conditioners to lubricate the hair shaft and give the hair a shiny appearance. The exact mechanism of action of Dexpanthenol is still unclear, perhaps through its enhancing effect on acetylcholine.

clear colorless to slightly yellow viscous liquid

ChEBI: Pantothenol is a monocarboxylic acid amide that is 3,3-dimethylbutanamide substituted by hydroxy groups at positions 2 and 4 and a 3-hydroxypropyl group at the carbomyl nitrogen. It has a role as a cholinergic drug and a provitamin. It is an amino alcohol and a monocarboxylic acid amide.

Dexpanthenol is an alcohol analog of pantothenic acid and an important component of parenterals, local cosmetic preparations and multi-vitamins. It has as much biological activity as pantothenic acid and is found to be stable in aqueous solution.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Moderately toxic by intravenous route. A skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx. See also AMIDES.

Dexpanthenol Basic Attributes

Molecular Weight：

205.25

BRN：

1724947

EC Number：

201-327-3

TSCA：

TSCA listed

Color/Form：

Clear colorless to slightly yellow

HScode：

29241990

Characteristics

Density：

1.20 g/mL at 20 °C (lit.)

Melting Point：

64～69℃

Boiling Point：

118-120 °C (2.7 mmHg)

Refractive Index：

1.495-1.502

Water Solubility：

soluble

Vapor Pressure：

0Pa at 25℃

Toxicity：

LD50 oral in mouse: 15gm/kg

Flammability characteristics：

Non flammable

PH：

pH (100g/l,25℃) : 8.5～10.5

PKA：

13.03±0.20(Predicted)

Critical Temperature & Pressure：

2-8°C

Safety Information

wgk germany：

hazard class code：

safety instructions：

23-24/25-45-36/37/39-26-22

RTECS Number：

ES4316000

Hazard Statements：

36/37/38-48-41-37/38-20/21/22

Exposure Prevention：

Pan(to)thenol is the alcohol corresponding to pantothenic acid, of the vitamin B5 group. It is used as a food additive, and in skin and hair products as a conditioning agent. Contact dermatitis and urticaria have been reported.

Dexpanthenol Use and Manufacturing

Dexpanthenol may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques as well as partial least-squares multivariate calibration.

cholinergic

D-Panthenol is an analogue of pantothenic acid (P190300), a member of the B complex vitamins. D-Panthenol is the biologically active enantiomer of Panthenol.

immunosuppressant, mitoxantrone analogue less toxic on cardiac tissue antineoplastic

Drug Function and Efficacy

Provitamin B5 that enhances skin hydration, supports tissue repair and has soothing effects

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

VIVALACARA DERMALERE ADVANCED SKIN CREAM- coconut, german chamomile, pot-marigold, helianthus annuus, d-panthenol, plantago major, urtica dioica, cotinus coggygria_cream
Manufacturer	Bodywell Natural Skin Care Inc

VIVALACARA DERMALERE ADVANCED BURN AND SCAR CREAM- coconut, chamomile, sunflower oil, dexpanthenol, plantago major, urtica dioica, cotinus coggygria,calendula officinalis flower_cream
Manufacturer	Bodywell Natural Skin Care Inc

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CAS No.: 81-13-0

Grade: Pharmaceutical Grade

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CAS No.: 81-13-0

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Content: 90%

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