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2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole

2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole structure

CAS No:
70006-24-5
Formula:
C17H19N5
Chemical Name:
2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole
Synonyms:
1H-Benzimidazole,2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-;2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole;2-[[4-(Pyridin-2-yl)piperazin-1-yl]methyl]-1H-benzimidazole;ABT 724;2-[[4-(Pyridin-2-yl)piperazin-1-yl]methyl]-1H-1,3-benzodiazole
Categories:
Chemical Reagents > Organic Reagents

Description

ABT-724 is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM). ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1].

2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole is a member of pyridines and a member of piperazines.

2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole Basic Attributes

Molecular Weight：

293.36600

Exact Mass：

293.37

UNII：

4WV2575JWT

Characteristics

PSA：

48.05000

XLogP3：

2.28300

Density：

1.275g/cm3

Melting Point：

220-221 °C @ Solvent: Ethanol, Hexane

Boiling Point：

548.6ºC at 760 mmHg

Flash Point：

285.6ºC

Refractive Index：

1.687

Water Solubility：

41.3 [ug/mL]

Storage Conditions：

Desiccate at +4ºC

Drug Information

MeSH Entry Terms：

2-((4-pyridin-2-ylpiperazine-1-yl)methyl)-1H-benzimidazole

Computed Properties

Molecular Weight:293.4
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:293.16404563
Monoisotopic Mass:293.16404563
Topological Polar Surface Area:48
Heavy Atom Count:22
Complexity:355
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole

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70006-24-5 2-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-benzimidazole

CAS No.: 70006-24-5

Grade: Industrial Grade

Content: 95%

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Guide of 2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Recommended Suppliers
Latest News
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2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole

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