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beta-Sitosterol

beta-Sitosterol structure

CAS No:
83-46-5
Formula:
C29H50O
Chemical Name:
beta-Sitosterol
Synonyms:
5-STIGMASTEN-3BETA-OL;22,23-DIHYDROSTIMASTEROL;24-ALPHA-ETHYLCHOLESTEROL;24BETA-ETHYLCHOLESTEROL;5-CHOLESTEN-24-BETA-ETHYL-3-BETA-OL;(3)-BETA-SITOSTEROL(2);ALPHA-DIHYDROFUCOSTEROL;ALPHA-PHYTOSTEROL
Categories:
Cosmetic Ingredient > Emulsion Stabilising

Description

Beta-Sitosterol weakly inhibits porcine pancreatic lipase (PPL) activity. Sitosterol is an important compound extracted from the leaves of Aloe vera.

Solid

Sitosterol is a member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3. It has a role as a sterol methyltransferase inhibitor, an anticholesteremic drug, an antioxidant, a plant metabolite and a mouse metabolite. It is a 3beta-sterol, a stigmastane sterol, a 3beta-hydroxy-Delta(5)-steroid and a member of phytosterols. It derives from a hydride of a stigmastane.|Active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity.

24α-ethyl Cholesterol is a naturally occurring plant sterol with antioxidant, anticancer, anti-inflammatory, angiogenic, chemopreventive, and immunomodulatory activities. It inhibits the absorption of dietary and endogenously-produced cholesterol from the small intestine, reducing blood cholesterol concentrations. Because of its nutraceutical benefits, 24α-ethyl cholesterol has been used as a food additive intended to lower LDL cholesterol. 24α-ethyl Cholesterol (0.1 -100 μM) can dose-dependently induce adipogenesis and lipolysis in rat primary preadipocytes as well as stimulate glucose uptake in differentiated adipocytes.

White powder

beta-Sitosterol Basic Attributes

Molecular Weight：

414.72

Exact Mass：

414.71

BRN：

1916165

EC Number：

201-480-6

UNII：

S347WMO6M4

NSC Number：

49083|18173|8096

DSSTox ID：

DTXSID5022481

Color/Form：

White to Off-White

HScode：

29061990

Characteristics

PSA：

20.23000

XLogP3：

9.3

Appearance：

Solid

Density：

0.9540 (rough estimate)

Melting Point：

136-140 °C(lit.)

Boiling Point：

473.52°C (rough estimate)

Flash Point：

220.4ºC

Refractive Index：

1.5000 (estimate)

Water Solubility：

INSOLUBLE

Storage Conditions：

-20ºC

PKA：

15.03±0.70(Predicted)

Critical Temperature & Pressure：

2-8°C

Safety Information

Packing level：

Ⅲ

Transport codes：

UN 1888 6.1/PG 3

wgk germany：

hazard class code：

Xn,Xi

safety instructions：

22-24/25-36-26-36/37

RTECS Number：

WJ2600000

Marks：

Precautionary statement(s)：

P201-P261-P304 + P340 + P312-P305 + P351 + P338-P308 + P313-P403 + P233

Hazard Statements：

22-38-40-48/20/22-36/37/38-67-36/38-20-63

RIDADR：

UN 1888 6.1/PG 3

GHS Classification：

Not Classified

Drug Information

MeSH：

Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS. (See all compounds classified as Hypolipidemic Agents.)

MeSH Entry Terms：

24-ethylcholest-5-en-3 beta-ol

beta-Sitosterol Use and Manufacturing

Uses

1. A common sterol in plants. Isolated from wheat germ oil, corn oil. Antilipemic. Used in the treatment of prostatic adenoma.
2. Antiinflammatory, immunomodulator

antiinflammatory, immunomodulator

Use Classification：

Lipids -> Sterol Lipids [ST] -> Sterols [ST01] -> Stigmasterols and C24-ethyl derivatives [ST0104]|Cosmetics -> Emulsion stabilizing; Skin conditioning; Stabilizing

Computed Properties

Molecular Weight:414.7
XLogP3:9.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:6
Exact Mass:414.386166214
Monoisotopic Mass:414.386166214
Topological Polar Surface Area:20.2
Heavy Atom Count:30
Complexity:634
Defined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It can quickly eliminate toxins from the body surface, have antibacterial effects, and promote the secretion of bile and pancreas.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Huangbo Capsule
Ingredients	Berberine, palmatine, phellodendronine, β-sitosterol, dithyrol.
Indication	Not yet clear
Specifications	0.33g per tablet
Manufacturer	Jiangxi Wohua Jishun Pharmaceutical Co., Ltd.

Huangbo Capsule
Ingredients	Berberine, palmatine, phellodendronine, β-sitosterol, dithyrol.
Indication	Not yet clear
Specifications	Each capsule contains 0.36 grams (equivalent to 1 gram of the original medicinal material)

Huangbo Capsule
Ingredients	Berberine, palmatine, phellodendronine, β-sitosterol, dithyrol.
Indication	Not yet clear
Specifications	Each capsule is equivalent to 1g of original medicinal material
Manufacturer	Guangdong Jiulianshan Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Shandong Ankang Pharmaceutical Co., Ltd.

China
Active
Zhejiang Delekang Food Co., Ltd.

China
Active
Zhejiang AngLiKang Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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CAS No.: 83-46-5

Grade: Cosmetics Grade

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Distributor Supplier of Di-p-toluoyl-D-tartaric acid

beta-Sitosterol used in food

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Trader Supplier of sunscreen ingredients,Dimethicone,Arbutin

Phytosterols Beta-Sitosterol

CAS No.: 83-46-5

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Weinan Rui Yuan Biological Technology Co., Ltd. Contact Supplier

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Manufactory Supplier

beta-Sitosterol 90% Pharmacy grade

CAS No.: 83-46-5

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Guide of beta-Sitosterol

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

beta-Sitosterol

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