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Proxyphylline

Proxyphylline structure

CAS No:
603-00-9
Formula:
C10H14N4O3
Chemical Name:
Proxyphylline
Synonyms:
1H-Purine-2,6-dione,3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-;Theophylline,7-(2-hydroxypropyl)-;3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6-dione;Brontyl;1,3-Dimethyl-7-(2-hydroxypropyl)xanthine;7-(β-Hydroxypropyl)theophylline;Proxyphylline;Purophyllin;7-(2-Hydroxypropyl)theophylline;Spasmolysin;Hydroxypropyltheophylline;2-Hydroxypropyl-7-theophylline;Oxypropyltheophylline;β-Hydroxypropyltheophylline;Proxiphylline;7-(β-Hydroxypropyl)-1,3-dimethylxanthine;Theoden;Sanwaphyllin;Sigophyl;Thean;Monophylline;2,6-Dioxo-3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethylpurine;(±)-Proxyphyllin;Proxy-Retardoral;Theon;Spantin;NSC 163343;86480-51-5
Categories:
Analytical Chemistry > Standard

Description

Proxyphylline is a methylxanthine derivative clinical used as cardiac stimulant, vasodilator and bronchodilator.

Proxyphylline is an oxopurine.|Proxyphylline is a methylxanthine and derivative of theophylline. Proxyphylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Proxyphylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart.

Proxyphylline Basic Attributes

Molecular Weight：

238.24

Exact Mass：

238.24

EC Number：

210-028-7

NSC Number：

759279|163343

DSSTox ID：

DTXSID5023536

NCI Thesaurus Code：

C80339

ATC Code：

R - Respiratory system

HScode：

2933990090

Characteristics

PSA：

78.7

XLogP3：

-0.8

Density：

1.46 g/cm3

Melting Point：

135.5 °C

Boiling Point：

487.2°C at 3 mmHg

Flash Point：

248.5ºC

Refractive Index：

1.664

Water Solubility：

>35.7 [ug/mL]

Storage Conditions：

Refrigerator

Collision Cross Section：

149.1 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

XH5907500

Marks：

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 41 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)

MeSH Entry Terms：

7-(2-hydroxypropyl)theophylline

Proxyphylline Use and Manufacturing

Uses

A metabolite of Theophylline

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:238.24
XLogP3:-0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:238.10659032
Monoisotopic Mass:238.10659032
Topological Polar Surface Area:78.7
Heavy Atom Count:17
Complexity:348
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Vitamins and minerals are both important substances that are essential for maintaining normal metabolism and health. They are important components of various coenzymes and hormones. Their deficiency can lead to metabolic disorders and cause various diseases.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Troxerutin Hydroxyphylline Tablets
Specifications	Troxerutin 45mg; Diphylline 60mg; Coumarin 2.5mg
Manufacturer	CSPC OUYI Pharmaceutical Co., Ltd.

Compound Hydroxypropyltheophylline and Dechlorazine Capsules
Ingredients	This product contains clenbuterol, hydroxypropylphylline, scopolamine, deschlorohydroxyzine, bromhexine, etc.
Indication	Not yet clear.
Specifications	Compound
Manufacturer	Suzhou No.3 Pharmaceutical Factory Co., Ltd.

Registered Holders

GANES CHEMICALS INC PENNSVILLE DIV

United States
Inactive

Recommended Suppliers of Proxyphylline

Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

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Proxyphylline603-00-9

CAS No.: 603-00-9

Grade: Reagent Grade

Content: 99%

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Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

Doxofylline Impurity 16

CAS No.: 603-00-9

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