 Home > Encyclopedia > Ethyl diazoacetate

Ethyl diazoacetate

Ethyl diazoacetate structure

CAS No:
623-73-4
Formula:
C4H6N2O2
Chemical Name:
Ethyl diazoacetate
Synonyms:
Acetic acid,2-diazo-,ethyl ester;Acetic acid,diazo-,ethyl ester;Diazoacetic acid ethyl ester;Ethyl diazoacetate;Ethoxycarbonyldiazomethane;Ethyl 2-diazoacetate;Diazoacetic ester;DAAE;Ethyl 2-diazoethanoate;NSC 79147;2-Diazo-1-ethoxyethanone;Ethyl α-diazoacetate;Ethanediazonium,2-ethoxy-2-oxo-,inner salt;623-74-5;14088-56-3;25386-24-7;27332-36-1;41810-60-0;622872-57-5;1007309-24-1;1968545-71-2
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Liquid.

Ethyl diazoacetate (N=N=CHC(O)OC2H5) is a diazo compound and a reagent in organic chemistry. It was discovered by Theodor Curtius in 1883. The compound can be prepared by reaction of the ethyl ester of glycine with sodium nitrite and sodium acetate in water.

Ethyl diazoacetate Basic Attributes

Molecular Weight：

114.103

Exact Mass：

114.042931

EC Number：

210-810-8

UNII：

N84B835FMR

NSC Number：

79147

HScode：

2927000090

Characteristics

PSA：

63.69000

XLogP3：

-0.57

Appearance：

colourless liquid

Density：

1.085 g/mL at 25 °C(lit.)

Melting Point：

-22 °C

Boiling Point：

145 °C

Flash Point：

115 °F

Refractive Index：

n20/D 1.46(lit.)

Storage Conditions：

2-8ºC

Safety Information

Packing level：

III

Hazard category：

3.2

Transport codes：

UN 1993 3/PG 3

wgk germany：

hazard class code：

R5;R10;R22;R40

safety instructions：

36/37

RTECS Number：

AG5775000

Marks：

Xn:Harmful;

Precautionary statement(s)：

P281

Hazard Statements：

H226-H242-H302-H351

RIDADR：

UN 1993

Caution Statement：

P281

GHS Classification：

|Warning|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P264, P270, P280, P301+P312, P303+P361+P353, P330, P370+P378, P403+P235, and P501|Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

diazoacetic ester

Ethyl diazoacetate Use and Manufacturing

Reagent for ruthenium-catalyzed asymmetric cyclopropanation of alkenes.1

Analysis Methods

Name	Column Shape	Active Phase(℃)	Retention index	Method	Comments	Reference
Normal alkane RI, non-polar column, temperature ramp	Capillary	HP-5 MS	840.	temperature ramp	25. m/0.20 mm/0.33 μm, Helium, 45. C @ 1. min, 5. K/min, 280. C @ 2. min	Kornilova, T.A.Ukolov, A.I.Kostikov, R.R.Zenkevich, I.G.Stability of diazocarbonyl compounds under the conditions of gas chromatography and chromatography-mass spectrometry analysisRus. J. General Chem.2012, 82, 10, 1675-1685.
Normal alkane RI, non-polar column, temperature ramp	Capillary	HP-5 MS	867.	temperature ramp	25. m/0.20 mm/0.33 μm, Helium, 45. C @ 1. min, 5. K/min, 280. C @ 2. min	Kornilova, T.A.Ukolov, A.I.Kostikov, R.R.Zenkevich, I.G.Stability of diazocarbonyl compounds under the conditions of gas chromatography and chromatography-mass spectrometry analysisRus. J. General Chem.2012, 82, 10, 1675-1685.
Normal alkane RI, non-polar column, temperature ramp	Capillary	OV-101	834.	temperature ramp	25. m/0.20 mm/0.10 μm, N2/He, 6. K/min; T_start: 50. C; T_end: 250. C	Zenkevich, I.G.Experimentally measured retention indices.2005.

Computed Properties

Molecular Weight:114.10
XLogP3:0.7
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:114.042927438
Monoisotopic Mass:114.042927438
Topological Polar Surface Area:28.3
Heavy Atom Count:8
Complexity:126
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Synthesis Route

Recommended Suppliers of Ethyl diazoacetate

NANTONG REFORM PETRO-CHEMICAL CO.,LTD Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Flavors & Fragrances,Catalyst & Auxiliary,Intermediates,Dyes & Pigments,Inorganic Chemistry,petro chemicals,Surfactant,Food Additives,Water Treatment Chemicals

Ethyl diazoacetate 623-73-4

CAS No.: 623-73-4

Grade: Industrial Grade

Content: 99%

Inquiry