1H-Benzimidazole-2-carboxamide(9CI)

At room temperature, A solution of 3.0 g (18.6 mmol) of 1 H-benzimidone-2-carboxylic acid was addedPlaced in1OOmL before the bottle, Add 30mL of thionyl chloride, 79 ° C reflux reaction 4h, After the reaction, dry the solvent. Add 30mL of ammonia, 70 ° C reaction 5h, cooling the reaction solution, Filtration of yellow solid, dry. Yield: 55.0percent.At room temperature, 3.0 g (18.6 mmol) of 1H-benzimidazole-2-carboxylic acid was placed in a 100 mL eggplant type flask, Add 30mL of thionyl chloride, 79 reflux reaction 4h, after the end of the reaction evaporated solvent.Add 30mL ammonia water, 70 reaction 5h, cooling the reaction solution, Filtration of yellow solid, dry. The yield was 55percent.

Molecular Weight:161.16
XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:161.058911855
Monoisotopic Mass:161.058911855
Topological Polar Surface Area:71.8
Heavy Atom Count:12
Complexity:195
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes