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Benperidol

Benperidol structure

CAS No:
2062-84-2
Formula:
C22H24FN3O2
Chemical Name:
Benperidol
Synonyms:
2H-Benzimidazol-2-one,1-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1,3-dihydro-;2-Benzimidazolinone,1-[1-[3-(p-fluorobenzoyl)propyl]-4-piperidyl]-;1-[1-[4-(4-Fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one;McN-JR 4584;Benperidol;Benzoperidol;Benzperidol;1-[1-[3-(p-Fluorobenzoyl)propyl]-4-piperidyl]-2-benzimidazolinone;1-(1-[4-(p-Fluorophenyl)-4-oxobutyl]piperidin-4-yl)-2-benzimidazolinone;Glianimon;Anquil;CB 8089;Frenactyl;R 4584;R 4730;Frenactil;NSC 170982;Benguil
Categories:
Analytical Chemistry > Standard

Description

White or almost white powder.

3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1H-benzimidazol-2-one is an aromatic ketone.|Benperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.|A butyrophenone with general properties similar to those of HALOPERIDOL. It has been used in the treatment of aberrant sexual behavior. (From Martindale, The Extra Pharmacopoeia, 30th ed, p567)

Benperidol Basic Attributes

Molecular Weight：

381.44

Exact Mass：

381.44

EC Number：

218-172-2

UNII：

97O6X78C53

NSC Number：

170982|169873

DSSTox ID：

DTXSID7045364

ATC Code：

N05AD07|N - Nervous system

Characteristics

PSA：

52.6

XLogP3：

4.09

Density：

1.2±0.1 g/cm3

Melting Point：

170-171.8 °C

Refractive Index：

1.595

Vapor Pressure：

7.96E-17mmHg at 25°C

Safety Information

Precautionary statement(s)：

P261, P264, P270, P271, P301+P312, P304+P312, P304+P340, P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P301+P312, P304+P312, P304+P340, P312, P330, and P501|Aggregated GHS information provided by 33 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)|Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

MeSH Entry Terms：

Anquil

Benperidol Use and Manufacturing

Uses

Antipsychotic.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:381.4
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:381.18525518
Monoisotopic Mass:381.18525518
Topological Polar Surface Area:52.6
Heavy Atom Count:28
Complexity:556
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes