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Pasiniazid

Pasiniazid structure

CAS No:
2066-89-9
Formula:
C7H7NO3.C6H7N3O
Chemical Name:
Pasiniazid
Synonyms:
4-Pyridinecarboxylic acid,hydrazide,compd. with 4-amino-2-hydroxybenzoate (1:1);Isonicotinic acid hydrazide,mono(4-aminosalicylate);4-Pyridinecarboxylic acid,hydrazide,mono(4-amino-2-hydroxybenzoate);Salicylic acid,4-amino-,compd. with isonicotinic acid hydrazide;Salicylic acid,4-amino-,compd. with isoniazid;Salicylic acid,4-amino-,compd. with isonicotinic acid hydrazide (1:1);Benzoic acid,4-amino-2-hydroxy-,compd. with 4-pyridinecarboxylic acid hydrazide (1:1);p-Aminosalicylic acid isonicotinyl hydrazide;Dipasic;Fintozid;Isoniazid 4-aminosalicylate;Pasiniazide;Pasiniazid;Isonicotinic acid hydrazide p-aminosalicylate;Nidrapas;Paraniazide;Parasal INH;Pascidaber;Pashain;Pas-Hidracida;GEWO 399;6190-85-8
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

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Description

Pasiniazid is an anti-TB and anti-leprosy drug, used to treat various types of TB and leprosy.

Pasiniazid Basic Attributes

Molecular Weight：

290.27

Exact Mass：

290.10200

EC Number：

218-183-2

UNII：

83J17CN0MN

NSC Number：

758447

DSSTox ID：

DTXSID50174700

HScode：

2933399090

Characteristics

PSA：

152

XLogP3：

2.03010

Appearance：

COA

Melting Point：

142-144 °C

Boiling Point：

380.8°C at 760 mmHg

Flash Point：

184.1ºC

Vapor Pressure：

1.78E-06mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

26-36/37

Marks：

Xn,Xi

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

Fintosid

Pasiniazid Use and Manufacturing

antibacterial (tuberculostatic)

Computed Properties

Molecular Weight:290.27
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:290.10150494
Monoisotopic Mass:290.10150494
Topological Polar Surface Area:152
Heavy Atom Count:21
Complexity:280
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a chemical synthesis of isoniazid (INH) and para-aminosalicylic acid (PAS). INH is mainly effective against mycobacteria in the growth and reproduction period, and may inhibit the synthesis of mycolic acid (myolic acid) of sensitive bacteria and cause cell wall rupture. PAS delays and blocks the acetylation process of INH in the body, enhances the bactericidal effect of the drug and delays the development of bacterial resistance. Clinically confirmed, in combination with other anti-tuberculosis drugs, the anti-tuberculosis efficacy of this product is significantly better than INH, and the incidence of adverse reactions is significantly lower than INH. Animal experiments show that the anti-tuberculosis efficacy of this product is about 5 times that of INH.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Para-aminosalicylic acid isoniazid tablets
Ingredients	The main ingredient of this product is isoniazid p-aminosalicylic acid.
Indication	Not yet clear.
Specifications	0.1 g
Manufacturer	Liaoning Kangboshi Pharmaceutical Co., Ltd.

Para-aminosalicylic acid isoniazid tablets
Ingredients	Isoniazid-para-aminosalicylate
Indication	Not yet clear.
Specifications	0.1g
Manufacturer	Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Pharmaceutical General

Pasniazid Tablets
Ingredients	The main ingredient of this product is isoniazid p-aminosalicylic acid.
Indication	Not yet clear.
Specifications	0.1g
Manufacturer	Guizhou Shenqi Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Chongqing Shengkai Pharmaceutical Co., Ltd.

China
Active
Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd.

China
Active
Guizhou Shenqi Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders