Methyldopate hydrochloride
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Methyldopate hydrochloride
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CAS No:
2508-79-4
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Formula:
C12H17NO4.ClH
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Chemical Name:
Methyldopate hydrochloride
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Synonyms:
L-Tyrosine,3-hydroxy-α-methyl-,ethyl ester,hydrochloride (1:1);Alanine,3-(3,4-dihydroxyphenyl)-2-methyl-,ethyl ester,hydrochloride,(-)-;L-Tyrosine,3-hydroxy-α-methyl-,ethyl ester,hydrochloride;Methyldopate hydrochloride;Methyldopa ethyl ester hydrochloride;α-Methyldopa ethyl ester hydrochloride;α-Methyl-L-dopa ethyl ester hydrochloride;Aldomet ester hydrochloride;956-43-4;5123-53-5;8054-31-7
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CAS No:
Description
Methyldopate Hydrochloride is the hydrochloride salt form of methyldopa, a phenylalanine derivate and aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure.
Methyldopate hydrochloride Basic Attributes
275.73
275.09200
219-720-3
7PX435DN5A
DTXSID1045370
C47617
2922504500
Methyldopate hydrochloride Use and Manufacturing
Ethyl methyldopate hydrochloride is Antihypertensive.
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:275.73
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:275.0924357
Monoisotopic Mass:275.0924357
Topological Polar Surface Area:92.8
Heavy Atom Count:18
Complexity:271
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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