1-Amino-2-methyl-2-propanol

Pale yellow liquid

3-Q-(2-hydroxy-2-methylpropylV2-neopentyl-lH-benzordlimidazol-5-ylsulfonylReference Example 41 Step 1 : Lithiumaluminiumhydride (2 M in tetrahydrofuran, 29.1 mL, 78.3 mmol) is diluted with dry tetrahydrofuran (90 mL) and cooled to 0 °C under nitrogen, acetonecyanohydrin (3.70 g, 39.1 mmol) in dry tetrahydrofuran (10 mL) is added dropwise and the mixture then heated at reflux for 4 hours. The mixture is cooled and the solvent evaporated under vacuum. A small amount of water is added to the residue and the mixture repeatedly extracted with ethyl acetate and dichloromethane. The combined organic extracts are evaporated to give crude 2-hydroxy- 2-methylpropylamine (Yield 1 .0 g). GC (METHOD 1 ): tIsobutylene oxide (415 mg, 5.76 mmol) and 28 mass percent aqueous ammonia were sealed in a reaction tube and heated at 120°C for 30 minutes with stirring and microwave irradiation. The solvent was removed by vacuum distillation to give the desired product (44percent yield) . Morphology: colorless oil 1H-NMR(CDClPreparation of compound 2-a To a round-bottomed flask charged with a magnet-bar NH4OH (60 mL), isobutylene oxide (10.0 g, 138.6 mmol) and MeOH (125 g) were added. The mixture was stirred at r.t. for 12 hrs, and then it was slowly heated to 60°C and stirred for 2-3hrs. The solvent was removed under reduced pressure, and the residue was distilled under atmospheric pressure to get the desired product (3.0 g, 33percent).5.91 g (50 mmol) of [beta] -hydroxyisovaleric acid was dissolved in 150 mL of THF, After adding 15 mL of N-methylmorpholine, 13.76 g (50 mmol) of diphenyl azide was added dropwise at room temperature, After 15 min dripping, the reaction was stirred for 4 h.Then add 60 mL of distilled water, stir and reflux for 2 h.After the reaction, the THF was evaporated under reduced pressure.Add 30 mL of ethyl acetate, stir, Adjust the pH to 2-3. The two phases were separated and the aqueous phase was extracted twice with ethyl acetate twice. The aqueous phase was further added 30 mL of ethyl acetate, Adjust the pH to 9 or so. Separate the two phases, extracted twice with water, 15 mL each time. Dried Na2SO4 and evaporated to dryness to obtain 3.79 gProduct (yield 85percent).

Molecular Weight:89.14
XLogP3:-0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:89.084063974
Monoisotopic Mass:89.084063974
Topological Polar Surface Area:46.2
Heavy Atom Count:6
Complexity:42.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes