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Corticosterone

Corticosterone structure

CAS No:
50-22-6
Formula:
C21H30O4
Chemical Name:
Corticosterone
Synonyms:
Pregn-4-ene-3,20-dione,11,21-dihydroxy-,(11β)-;Corticosterone;(11β)-11,21-Dihydroxypregn-4-ene-3,20-dione;11,21-Dihydroxyprogesterone;Kendall's compound B;4-Pregnene-11β,21-diol-3,20-dione;Reichstein's substance H;17-Deoxycortisol;11β,21-Dihydroxypregn-4-ene-3,20-dione;11-Hydroxycorticoaldosterone;11β,21-Dihydroxyprogesterone;Corticosteron;NSC 9705;67085-09-0;74339-96-1;1050677-95-6
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

Solid

Corticosterone is a 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. It has a role as a human metabolite and a mouse metabolite. It is an 11beta-hydroxy steroid, a 21-hydroxy steroid, a 20-oxo steroid, a C21-steroid, a 3-oxo-Delta(4) steroid, a primary alpha-hydroxy ketone and a glucocorticoid. It derives from a hydride of a pregnane.|An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)|Corticosterone is a corticosteroid intermediate in the steroidogenic pathway that converts pregnenolone to aldosterone. In humans, corticosterone has limited glucocorticoid or mineralocorticoid activity.

Corticosterone Basic Attributes

Molecular Weight：

346.46100

Exact Mass：

346.46

EC Number：

200-019-6

UNII：

W980KJ009P

NSC Number：

9705

DSSTox ID：

DTXSID6022474

NCI Thesaurus Code：

C393

HScode：

29372900

Characteristics

PSA：

74.60000

XLogP3：

2.66670

Appearance：

Solid

Density：

1.21g/cm3

Melting Point：

181 °C

Boiling Point：

529.2ºC at 760mmHg

Flash Point：

288ºC

Refractive Index：

1.575

Water Solubility：

240.5mg/L(37 ºC)

Storage Conditions：

Store at RT

Collision Cross Section：

186.8 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|186.46 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|186.9 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|208.4 Å² [M+K]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|211.8 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|186.8 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|186.8 Å² [M-H]-

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R43

safety instructions：

36-22

RTECS Number：

GM7650000

Marks：

Xi; N; Xn; T

Stability/Shelf Life：

Stable, but light sensitive. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P280

Hazard Statements：

H317

GHS Classification：

|Warning|H317 (97.5%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P302+P352, P321, P333+P313, P363, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

MeSH Entry Terms：

Corticosterone

Corticosterone Use and Manufacturing

Uses

1. Glucocorticoid; an intermediate in the biosynthesis of aldosterone, isolated from the adrenal cortex.
2. Corticosteroid is an activator of MCR.

Use Classification：

Lipids -> Sterol Lipids [ST] -> Steroids [ST02] -> C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives [ST0203]|Pharmaceuticals

Computed Properties

Molecular Weight:346.5
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:346.21440943
Monoisotopic Mass:346.21440943
Topological Polar Surface Area:74.6
Heavy Atom Count:25
Complexity:638
Defined Atom Stereocenter Count:7
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Progesterone

1-Propanol

Sulfuric acid

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