5,5-Diethyl-1-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione
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5,5-Diethyl-1-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione
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CAS No:
357-67-5
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Formula:
C14H16N2O3
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Chemical Name:
5,5-Diethyl-1-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione
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Synonyms:
2,4,6(1H,3H,5H)-Pyrimidinetrione,5,5-diethyl-1-phenyl-;Barbituric acid,5,5-diethyl-1-phenyl-;5,5-Diethyl-1-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione;5,5-Diethyl-1-phenylbarbituric acid;N-Phenylbarbital;Phetharbital;1-Phenyl-5,5-diethylbarbituric acid;5,5-Diethyl-2,4,6-trioxo-1-phenylhexahydropyrimidine;Phenidiemal;Fedibaretta;Pyrictal;N-Phenylbarbitone;Phenetharbital;NSC 85043
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CAS No:
Description
Phetharbital is a member of barbiturates.|Phetharbital is a short-acting barbiturate derivative without hypnotic properties, Phetharbital (N-phenylbarbital) can be used as a sedative and anticonvulsant agent due to its mechanism of enhancing GABA (Gamma Amino Butyric Acid) transmission and inhibition of synaptic excitation. Phetharbital has generally been withdrawn from clinical use. (NCI04)
5,5-Diethyl-1-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione Basic Attributes
260.293
260.29
206-615-2
52HG53W51E
85043
DTXSID30189216
C29320
2933540000
Drug Information
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)|Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)
5,5-diethyl-1-phenylbarbituric acid
Computed Properties
Molecular Weight:260.29
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:260.11609238
Monoisotopic Mass:260.11609238
Topological Polar Surface Area:66.5
Heavy Atom Count:19
Complexity:396
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
5,5-Diethyl-1-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione
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