 Home > Encyclopedia > L-Selenomethionine

L-Selenomethionine

L-Selenomethionine structure

CAS No:
3211-76-5
Formula:
C5H11NO2Se
Chemical Name:
L-Selenomethionine
Synonyms:
Butanoic acid,2-amino-4-(methylseleno)-,(2S)-;Butyric acid,2-amino-4-(methylselenyl)-,L-;Butanoic acid,2-amino-4-(methylseleno)-,(S)-;(2S)-2-Amino-4-(methylseleno)butanoic acid;Seleno-L-methionine;Selenomethionine;L-Selenomethionine;SelenoSource AF 2000;Selenomax;SelenoSource AF 600;SelenoSource AF;Vitaselenium;Prince Se Yeast 2000;(2S)-2-Azaniumyl-4-methylselanylbutanoate
Categories:
Biochemical Engineering > Amino Acids and Derivatives

Description

L-SelenoMethionine is a major natural food-form of selenium.Target：The median lethal dose (LD50) of L-SelenoMethionine in rats given an intraperitoneal injection was determined to 4.25 mg Se/kg body and thus is comparable to that of selenite or selenate. In mice, the LD50 of L-SelenoMethionine was 8.8 ± 1.37 mg Se/kg, and the minimal lethal dose, 4.0 mg Se/kg, after intravenous injection.

Solid

L-selenomethionine is the L-enantiomer of selenomethionine. It is an enantiomer of a D-selenomethionine. It is a tautomer of a L-selenomethionine zwitterion.|Selenomethionine is a naturally occuring amino acid in some plant materials such as cereal grains, soybeans and enriched yeast but it cannot be synthesized from animals or humans. It can be produced from post-structural modifications. *In vivo*, selenomethionine plays an essential role in acting as an antioxidant, where it depletes reactive oxygen species (ROS) and aids in the formation and recycling of glutathione, another important antioxidant. In comparison to selenite, which is the inorganic form of selenium, the organic form of selenomethionine is more readily absorbed in the human body. Selenomethionin is used in biochemical laboratories where its incorporation into proteins that need to be visualized enhances the performance of X-ray crystallography.|L-Selenomethionine is the amino acid methionine with selenium substituting for the sulphur moiety. Methionine is an essential amino acid in humans, whereas selenium is a free-radical scavenging anti-oxidant, essential for the protection of various tissues from the damages of lipid peroxidation. As a trace mineral that is toxic in high doses, selenium is a cofactor for glutathione peroxidase, an anti-oxidant enzyme that neutralizes hydrogen peroxide. L-Selenomethionine is considered a safe, efficacious form of selenium and is readily bioavailable. Selenium may be chemoprotective for certain cancers, particularly prostate cancer. (NCI04)|Diagnostic aid in pancreas function determination.

L-Selenomethionine Basic Attributes

Molecular Weight：

196.11

Exact Mass：

196.11

EC Number：

2017-001-1

UNII：

964MRK2PEL

NSC Number：

760370

DSSTox ID：

DTXSID8046824

NCI Thesaurus Code：

C2833

HScode：

2922499990

Characteristics

PSA：

63.3

XLogP3：

0.65930

Appearance：

white to off-white powder

Melting Point：

275 °C (decomp)

Boiling Point：

320.78°C at 760 mmHg

Flash Point：

147.8±26.5 °C

Refractive Index：

18 ° (C=0.5, 2mol/L HCl)

Water Solubility：

H2O: 50 mg/mL

Storage Conditions：

−20°C

Specific rotation：

18 º (c=1, 1N HCl)

Collision Cross Section：

137.67 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|150 Å² [M-H]-

Safety Information

Packing level：

I; II; III

Hazard category：

6.1

Transport codes：

UN 3283 6.1/PG 2

wgk germany：

hazard class code：

23/25-33-50/53

safety instructions：

20/21-28-45-60-61-28A

RTECS Number：

EK7713840

Marks：

T,N

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

Missing Phrase - N15.00950417-P260-P304 + P340 + P312-P403 + P233

Hazard Statements：

H301 + H331-H373-H410

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P273, P301+P310, P304+P340, P311, P314, P321, P330, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 95 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

Butanoic acid, 2-amino-4-(methylseleno)-

L-Selenomethionine Use and Manufacturing

Methods of Manufacturing

Under a nitrogen atmosphere, 13.75 g of α-amino-γ-butyrolactone hydrochloride was mixed with 40 mL of DMF, Stir evenly. 15.2 g of sodium methyl selenate was dissolved in 20 mL of DMF, added to the above system and refluxed for 2 h. After the reaction was completed, the pH of the system was adjusted to 6.0 with an aqueous acetic acid solution to give a white solid, Solid water and ethanol mixed solution recrystallization, both L-selenomethionine. The total yield was 72.11percentChemical purity> 99percent, ee> 99percent.

Uses

A compound shown to increase expression of glutathione peroxidase

Use Classification：

Human drugs -> Rare disease (orphan)

Computed Properties

Molecular Weight:196.12
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:196.99550
Monoisotopic Mass:196.99550
Topological Polar Surface Area:63.3
Heavy Atom Count:9
Complexity:97
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Benzyl chloride

Tetrahydrofuran

Sodium hydroxide

Sodium bicarbonate

Ethanol

Acetone

Dimethylformamide

Benzene

Hydrochloric acid

Sodium chloride

Ammonia

Sulfuric acid

Hydrogen peroxide

Recommended Suppliers of L-Selenomethionine

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

L-Selenomethionine 10g High Quality Shaanxi Dideu Medichem Co.Ltd

Unit Price: $200 /G FOB

CAS No.: 3211-76-5

Grade: Industrial Grade

Content: 98%

Inquiry
Xi'an Lanshan Biotechnology Co., Ltd. Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of Tranexamic acid,Plant extracts,nmn,Alpha Arbutin,food additives,ecdysone,Cosmetic raw materials,β-Hydroxybutyric acid

L-Selenome 3211-76-5

CAS No.: 3211-76-5

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Creative Enzymes Contact Supplier

US
6 YRS

Business licensed Certified factory

Manufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates

L-Selenomethionine

CAS No.: 3211-76-5

Inquiry
Hangzhou Source Herb Bio-Tech Co., Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Red Yeast Rice,Saw Palmetto Extract,Berberine HCL

Factory Supply High Quality Selenium Methionine Powder

CAS No.: 3211-76-5

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Xian ZB Biotech Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Herb Extracts,Cosmetic raw materails,API

L-Selenomethionine

CAS No.: 3211-76-5

Grade: Pharmaceutical grade

Content: 0.99%

Inquiry

Learn More Other Chemicals

L-Glutamic acid, N-[3-carboxy-2-(carboxymethyl)-2-hydroxy-1-oxopropyl]-

73590-26-8
1-chloro-6-Methyl-5-nitroisoquinoline

943606-84-6
2-chloro-N-(2-oxothiolan-3-yl)acetamide

84611-22-3
N-[(Phenylmethoxy)carbonyl]-L-phenylalanylglycine Formula

13122-99-1
(αR)-α-[(Methoxycarbonyl)amino]benzeneacetic acid Formula

50890-96-5
3,4,5-Trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)-benzamide Formula

461000-66-8
5-(4-Hydroxyphenyl)-2,4-imidazolidinedione Structure

2420-17-9
γ-Aminobenzenepropanol Structure

14593-04-5
What is 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

170491-63-1
What is (R)-3-AMINO-3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID

774178-39-1

Hot Searches: thymosin alpha-1 for sale; buy masteron; white phosphorus price; thorium metal for sale; 5989-27-5; 1 4 butanediol buy

Guide of L-Selenomethionine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Material
Recommended Suppliers
Learn More Other Chemicals

L-Selenomethionine

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.