Benzenesulfonamide,3-cyano-(9CI)

NHStep 1: 3-cyanobenzenesulfonamideTo a solution of ammonia in dioxane (0.5 M in dioxane; 50 mlA solution of 3-cyano-benzenesulfonyl chloride (1.07 g) in ammonia (33percent aqueous solution, 40 mL) was stirred for 1 h and then evaporated under reduced pressure to approx. 20 mL and cooled. The precipitate was filtered and washed with water and dried in vaccuo to afford the intermediate (722 mg; 75percent) as a colourless solid. [MH]A solution of commercially available 3-cyano-benzenesulfonyl chloride (1.07 g) in a 33percent solution of NHr under the protection, 3-cyanobenzenesulfonyl chloride (400 mg, 2. Ommo 1) Excess ammonia methanol solution (3.5 mL, 17.5 mmol) Ice bath to room temperature reaction, 0.5h after stopping the reaction, steaming solution, adding 10mL of ice water, DCM extracted four times, combined organic phase, recrystallized pale yellow solid (206mg 56.6percent)General procedure: 1Nu-benzylbenzenesulfonamide: In the reaction vessel, 0.50 mmol of benzyl alcohol and 2.5 mmol of benzenesulfonamide were added, and 0.05 mmol of 2, 3-difluoropyridineboronic acid, 0.05 mmol of oxalic acid dihydrate and 2 mL of fluorobenzene were sequentially added. It was placed in a microwave reactor and heated at 80 W for 150 min for 30 min. After the reaction was completed, it was cooled to room temperature and concentrated under reduced pressure, the product was purified by column chromatography to give a white solid, yield was 82%.2-Chloro-6-[3-[[l-(trifluoromethyl)cyclopropyl]methoxy]pyrazol-l-yl]pyridine-3-carboxylic acid (200 mg, 0.5529 mmol) and CDI (approximately 107.6 mg, 0.6635 mmol) were combined in THF (1.200 mL) and stirred at room temperature for 2 hours. Ar under the protection, Methyl-4 - ((3-methoxyphenyl) amino) -7-chloro-111-indole-2-carboxylic acid (801 ^ 0 · 24mmo 1) Dissolved in dry DCM, Followed by addition of HATU (140 mg, 0.36 mmo 1) DMAP (15 mg, 0.12 mmo 1) And TEA (73 mg, 0.72 mmo 1), After stirring,

Molecular Weight:182.20
XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:182.01499861
Monoisotopic Mass:182.01499861
Topological Polar Surface Area:92.3
Heavy Atom Count:12
Complexity:295
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes