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3-Amino-2-oxazolidinone

3-Amino-2-oxazolidinone structure

CAS No:
80-65-9
Formula:
C3H6N2O2
Chemical Name:
3-Amino-2-oxazolidinone
Synonyms:
2-Oxazolidinone,3-amino-;3-Amino-2-oxazolidinone;3-Amino-2-oxazolidone;3-Amino-1,3-oxazolidin-2-one;NSC 111187;NSC 196570;NSC 38250
Categories:
Analytical Chemistry > Standard

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Description

White Solid

3-Amino-2-oxazolidone is an oxazolidinone.

3-Amino-2-oxazolidinone Basic Attributes

Molecular Weight：

102.09

Exact Mass：

102.09

EC Number：

201-299-2

UNII：

VJ7HE86A15

NSC Number：

196570|111187|38250

DSSTox ID：

DTXSID00229996

HScode：

29349990

Characteristics

PSA：

55.6

XLogP3：

-0.8

Density：

1.4±0.1 g/cm3

Melting Point：

34 °C

Boiling Point：

130-135 °C @ Press: 10 Torr

Flash Point：

54.9±22.6 °C

Refractive Index：

1.518

Storage Conditions：

0-6°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36/37

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

3-amino-2-oxazolidinone

3-Amino-2-oxazolidinone Use and Manufacturing

Methods of Manufacturing

Obtained by β-hydroxyethyl urea through nitrosation, cyclization and reduction. The aqueous solution of β-hydroxyethyl urea and sodium nitrite were mixed, cooled to 0-3°C, added dropwise to hydrochloric acid, and the temperature was kept below 28°C. After the addition, the temperature was raised to 40-45°C and the reaction was conducted for half an hour. Cool down to 0-3°C, and then add sodium nitrite solution dropwise. Add crushed ice to cool to -20℃, add iron powder to react for half an hour, filter, and the filtrate is 3-amino-2-oxazolidinone aqueous solution.

Uses

A metabolite of Furazolidone and Nitrofuran.

Computed Properties

Molecular Weight:102.09
XLogP3:-0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:102.042927438
Monoisotopic Mass:102.042927438
Topological Polar Surface Area:55.6
Heavy Atom Count:7
Complexity:92.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Diethyl carbonate