2-Chloro-5-fluoro-4-pyrimidinamine
-
2-Chloro-5-fluoro-4-pyrimidinamine
structure -
-
CAS No:
155-10-2
-
Formula:
C4H3ClFN3
-
Chemical Name:
2-Chloro-5-fluoro-4-pyrimidinamine
-
Synonyms:
4-Pyrimidinamine,2-chloro-5-fluoro-;Pyrimidine,4-amino-2-chloro-5-fluoro-;2-Chloro-5-fluoro-4-pyrimidinamine;4-Amino-2-chloro-5-fluoropyrimidine;2-Chloro-5-fluoropyrimidin-4-ylamine;NSC 78716;2-Chloro-5-fluoropyrimidin-4-amine;2-Chloro-5-fluoro-4-aminopyrimidine
- Categories:
-
CAS No:
Characteristics
51.8
0.9
White to light yellow Crystalline Powder
1.564±0.06 g/cm3(Predicted)
191-193 °C @ Solvent: Water
318.5±22.0 °C(Predicted)
146.4±22.3 °C
1.584
H2O: REACTS VIOLENTLY
0mmHg at 25°C
Safety Information
NONH for all modes of transport
3
22
Xi,Xn
P264, P270, P301+P312, P330, P501
H302
|Warning|H302 (92.68%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 41 companies from 4 notifications to the ECHA C&L Inventory.
2-Chloro-5-fluoro-4-pyrimidinamine Use and Manufacturing
10287] 0.15 g (1.01 mmol) of 2-chloro-5-fluoropyrimi- dine-4-amine, 0.249 g (1.22 mmol) of (2-methyl-4, 5, 6, 7- tetrahydrobenzothiophen-4-yl)ammonium chloride and 0.63 g (0.68 ml, 3.05 mol) of dicyclohexylethylamine in 2.0 ml of 1-methyl-2-pyrrolidone are heated at 180 C. in a closed cuvette in the microwave for 90 minutes (l3iotage Initiator, http://www.biotage.comlproduct-page/biotage-initiator).The crude mixture thus obtained is applied to silica gel and purified by column chromatography with heptane/ethyl acetate as mobile phase. Concentration gives 0.072 g of 5-fluoro-N2-(2-methyl-4, 5, 6, 7-tetrahydro- 1 -benzothiophen-4-yl)pyrimidine-2, 4-diamine (in waxy form) (22% yield at 85% purity).
Fluorocytosine intermediate.
Computed Properties
Molecular Weight:147.54
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Exact Mass:146.9999530
Monoisotopic Mass:146.9999530
Topological Polar Surface Area:51.8
Heavy Atom Count:9
Complexity:102
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2-Chloro-5-fluoro-4-pyrimidinamine
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
5 YRS
Business licensed Certified factoryManufactory Supplier of Active Pharm Ingredients,Chemical Catalyst,Pharmaceutical Intermediates,Flavors and Fragrances,Agrochemicals,Chemical Pesticides,Organic Intermediates,OLED IntermediatesInquiryCAS No.: 155-10-2Grade: Pharmaceutical GradeContent: 99% -
![United States]()
US
6 YRS
Business licensed Certified factoryManufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates
Learn More Other Chemicals
-
(2E)-3-(1-METHYL-1H-PYRROL-2-YL)ACRYLIC ACID
51485-76-8
-
Benadryl N-oxide hydrochloride
13168-00-8
-
6-CHLORO-3-IODO-IMIDAZO[1,2-A]PYRIDINE
885275-59-2
-
(2-Bromophenyl)diphenylphosphine Formula
62336-24-7
-
1-Morpholinocyclopentene Formula
936-52-7
-
4-[2-(Boc-amino)ethoxy]-benzoic acid Formula
168892-66-8
-
3-amino-5-bromopyridine-2-carboxylic acid Structure
870997-85-6
-
2-Amino-6-methylpyridine Structure
1824-81-3
-
What is 3-Bromo-2-methylthiophene
30319-05-2
-
What is THIOPHEN-2-YLMETHYL-PHOSPHONICACIDDIETHYLESTER
2026-42-8
2-Chloro-5-fluoro-4-pyrimidinamine
SDSRequest for Quotation