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6(5H)-Phenanthridinone

6(5H)-Phenanthridinone structure

CAS No:
1015-89-0
Formula:
C13H9NO
Chemical Name:
6(5H)-Phenanthridinone
Synonyms:
6(5H)-Phenanthridinone;6-Phenanthridinol;6-Phenanthridone;6-Phenanthridinone;PJ 97A;5H-Phenanthridin-6-one;NSC 11021;NSC 40943;NSC 61083;WD 99-004344;Phenanthridinone
Categories:
Chemical Reagents > Organic Reagents

Description

ChEBI: A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.

Phenanthridone is a member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity. It has a role as a mutagen, an immunosuppressive agent and an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor. It is a lactam and a member of phenanthridines.

6(5H)-Phenanthridinone Basic Attributes

Molecular Weight：

195.22

Exact Mass：

195.22

BRN：

140641

EC Number：

213-804-3

UNII：

AVQ13AUB5J

NSC Number：

61083|40943|11021

DSSTox ID：

DTXSID0074423

HScode：

29337900

Characteristics

PSA：

29.1

XLogP3：

2.5

Density：

1.230±0.06 g/cm3(Predicted)

Melting Point：

>300 °C

Boiling Point：

435 °C

Flash Point：

158.7±3.1 °C

Refractive Index：

1.642

Water Solubility：

Soluble in DMSO (5 mg/ml). Insoluble in water.

Storage Conditions：

2-8°C

Vapor Pressure：

0.005mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

RTECS Number：

SG0370000

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Chemicals and drugs that inhibit the action of POLY(ADP-RIBOSE)POLYMERASES. (See all compounds classified as Poly(ADP-ribose) Polymerase Inhibitors.)

MeSH Entry Terms：

6(5H)-phenanthridinone

6(5H)-Phenanthridinone Use and Manufacturing

6-Phenanthridone is a poly(ADP-ribose) polymerase (PARP) inhibitor with immunosuppressive effects. 6-Phenanthridone has been shown to inhibit concanavalin A-induced lymphocyte proliferation.

Computed Properties

Molecular Weight:195.22
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:195.068413911
Monoisotopic Mass:195.068413911
Topological Polar Surface Area:29.1
Heavy Atom Count:15
Complexity:263
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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