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Protriptyline hydrochloride

Protriptyline hydrochloride structure

CAS No:
1225-55-4
Formula:
C19H21N.ClH
Chemical Name:
Protriptyline hydrochloride
Synonyms:
5H-Dibenzo[a,d]cycloheptene-5-propanamine,N-methyl-,hydrochloride (1:1);5H-Dibenzo[a,d]cycloheptene-5-propylamine,N-methyl-,hydrochloride;5H-Dibenzo[a,d]cycloheptene-5-propanamine,N-methyl-,hydrochloride;MK-240;N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine hydrochloride;Normethyl EX4442;Protriptyline hydrochloride;Triptil Hydrochloride;Vivactil;Concordin;Maximed;Triptil;Protryptyline hydrochloride;Maximet
Categories:
Analytical Chemistry > Standard

Description

Protriptyline is a tricyclic antidepressant (TCA), specifically a secondary amine, for the treatment of depression and ADHD. Unique among the TCAs, protriptyline tends to be energizing instead of sedating, used for narcolepsy to achieve a wakefulness-promoting effect.

Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with antidepressant property. Protriptyline hydrochloride blocks the re-uptake of norepinephrine and serotonin by nerve terminals, thereby increasing available norepinephrine and serotonin. Protriptyline does not block dopamine transport but may have an indirect dopamine-facilitating effect through interactions of increased peri-synaptic abundance of norepinephrine, particularly in the cerebral cortex, where adrenergic terminals exceed dopaminergic terminals. This results in elevation of mood and behavioral activity. In addition, this agent exhibits anticholinergic activity.|Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation.

Protriptyline hydrochloride Basic Attributes

Molecular Weight：

299.84

Exact Mass：

299.144073

EC Number：

214-956-3

UNII：

44665V00O8

NSC Number：

759297|169912

DSSTox ID：

DTXSID8046951

NCI Thesaurus Code：

C47695

Characteristics

PSA：

12.03000

XLogP3：

5.49480

Appearance：

white to off-white

Melting Point：

169-171 °C

Boiling Point：

407.7ºC at 760 mmHg

Flash Point：

9℃

Water Solubility：

H2O: soluble50mg/mL

Storage Conditions：

2-8°C

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

hazard class code：

20/21/22-36/37/38-39/23/24/25-23/24/25-11

safety instructions：

26-36-45-36/37-16-7

RTECS Number：

HP1400000

Marks：

Xn,T,F

Precautionary statement(s)：

P261-P280-P301 + P310-P305 + P351 + P338

Hazard Statements：

H301-H312-H315-H319-H332-H335

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)|Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)

MeSH Entry Terms：

Hydrochloride, Protriptyline

Protriptyline hydrochloride Use and Manufacturing

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:299.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:299.1440774
Monoisotopic Mass:299.1440774
Topological Polar Surface Area:12
Heavy Atom Count:21
Complexity:296
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Latest News on Protriptyline hydrochloride

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Guide of Protriptyline hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Latest News
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Protriptyline hydrochloride

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