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Hispidulin

Hispidulin structure

CAS No:
1447-88-7
Formula:
C16H12O6
Chemical Name:
Hispidulin
Synonyms:
4H-1-Benzopyran-4-one,5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-;Flavone,4′,5,7-trihydroxy-6-methoxy-;5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one;Dinatin;Hispidulin;4′,5,7-Trihydroxy-6-methoxyflavone;5,7,4′-Trihydroxy-6-methoxyflavone;6-Methoxyapigenin;Salvitin;6-Methoxy-5,7,4′-trihydroxyflavone;Scutellarein 6-methyl ether;Hispedulin;NSC 122415;6-Methylscutellarein;Hispiludin;6-O-Methylscutellarein
Categories:
Natural Products > Flavonoids

Description

ChEBI: A monomethoxyflavone that is scutellarein methylated at position 6.

Hispidulin is a monomethoxyflavone that is scutellarein methylated at position 6. It has a role as an apoptosis inducer, an anti-inflammatory agent, an antioxidant, an anticonvulsant, an antineoplastic agent and a plant metabolite. It is a trihydroxyflavone and a monomethoxyflavone. It derives from a scutellarein.|Hispidulin (4',5,7-trihydroxy-6-methoxyflavone) is a potent benzodiazepine (BZD) receptor ligand with positive allosteric properties.

Hispidulin Basic Attributes

Molecular Weight：

300.26

Exact Mass：

300.26

UNII：

N7F61604C2

NSC Number：

122415

DSSTox ID：

DTXSID30162786

HScode：

2914509090

Characteristics

PSA：

96.2

XLogP3：

1.60

Appearance：

white to beige

Density：

1.512±0.06 g/cm3(Predicted)

Melting Point：

291-292 °C

Boiling Point：

601.5±55.0 °C(Predicted)

Flash Point：

230.1±25.0 °C

Refractive Index：

1.697

Water Solubility：

DMSO: soluble20mg/mL, clear

Storage Conditions：

Desiccate at -20°C

Vapor Pressure：

4.61E-15mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

RTECS Number：

DJ2996000

Marks：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

Drug Information

MeSH Entry Terms：

4',5,7-trihydroxy-6-methoxy-flavone

Hispidulin Use and Manufacturing

Uses

Partial positive allosteric modulator at the benzodiazepine receptor (IC 50 = 1.3 μ M for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α 1 α 2-, α 3-, α 5- or α 6- β 2 γ 2S GABA A receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properti

Use Classification：

Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]

Computed Properties

Molecular Weight:300.26
XLogP3:1.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:300.06338810
Monoisotopic Mass:300.06338810
Topological Polar Surface Area:96.2
Heavy Atom Count:22
Complexity:454
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Hispidulin

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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5 YRS

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Hispidulin

CAS No.: 1447-88-7

Content: 99.00%

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Wuhan Pnq Int Trade Co., Ltd Contact Supplier

CN
3 YRS

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Hispidulin, CAS:1447-88-7

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CAS No.: 1447-88-7

Grade: Chemical Grade

Content: 99%

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Guide of Hispidulin

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Hispidulin

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