2-Amino-5-nitrobenzophenone
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2-Amino-5-nitrobenzophenone
structure -
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CAS No:
1775-95-7
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Formula:
C13H10N2O3
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Chemical Name:
2-Amino-5-nitrobenzophenone
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Synonyms:
Methanone,(2-amino-5-nitrophenyl)phenyl-;Benzophenone,2-amino-5-nitro-;(2-Amino-5-nitrophenyl)phenylmethanone;2-Amino-5-nitrobenzophenone;5-Nitro-2-aminobenzophenone;Ro 7-19990;2-Benzoyl-4-nitroaniline
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CAS No:
Characteristics
88.9
3
yellow solid
1.2480 (rough estimate)
160.1 °C
385.05°C (rough estimate)
242.9±25.9 °C
1.5300 (estimate)
3 mg/L (20 C)
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
2.65E-09mmHg at 25°C
Safety Information
NONH for all modes of transport
3
36/37/38-20/21/22
26-37/39-36
PC4935000
Xi,Xn
Stable under normal temperatures and pressures.
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (97.87%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 47 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Amino-5-nitrobenzophenone Use and Manufacturing
From the condensation of p-nitroaniline and benzoyl chloride. Add p-nitroaniline, benzoyl chloride and zinc chloride into the reaction tank and stir, heating to melt all the materials. Raise the temperature to 140℃ and keep it warm for 30min. Continue to heat up to about 200 ℃, heat preservation reaction for 2h, cool to 115-120 ℃, stirring hydrolysis for 15h. Add 2.5 times diluted hydrochloric acid, cool to 35°C and filter. The filter cake was washed with dilute hydrochloric acid and filtered to dry. Add 4 times the amount of water and stir into a paste, add alkali to pH 11 and soak for 2-3 hours (add alkali during soaking, add alkali to pH 11). Filter and wash the filter cake with water to bring the pH to 6-7. Filter and dry to obtain crude benzophenone. Add appropriate amount of activated carbon and 10 times the amount of ethanol and heat to reflux for 4h. Filter while hot. The filtrate is cooled and crystallized. Filtration is carried out, the filter cake is washed with cold ethanol, filtered and dried. The yield was 25%.
A metabolite of Nitrazepam
Computed Properties
Molecular Weight:242.23
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:242.06914219
Monoisotopic Mass:242.06914219
Topological Polar Surface Area:88.9
Heavy Atom Count:18
Complexity:321
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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