Teriparatide acetate
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Teriparatide acetate
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CAS No:
52232-67-4
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Formula:
C181H291N55O51S2.C2H4O2
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Chemical Name:
Teriparatide acetate
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Synonyms:
Parathyroid hormone human: fragment 1-34;parathyroid hormone (human, 1-34);parathyroid hormone (1-34), human;pth (1-34) (human);pth (human, 1-34);teriparatide;teriparatide acetate;
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CAS No:
Description
Teriparatide is a PHT agonist, with an IC50 of 2 nM in HEK293 cells. Sequence: Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe.
Teriparatide acetate Use and Manufacturing
A fragment of human parathyroid hormone (hPTH) peptide sequence containing the 34 N-terminal residues of hPTH. This fragment was also found to be an agonist at PTH1 and PTH2 receptors.
Computed Properties
Molecular Weight:4118
XLogP3:-18.7
Hydrogen Bond Donor Count:60
Hydrogen Bond Acceptor Count:62
Rotatable Bond Count:146
Exact Mass:4116.1342973
Monoisotopic Mass:4115.1309424
Topological Polar Surface Area:1800
Heavy Atom Count:289
Complexity:9740
Undefined Atom Stereocenter Count:34
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Not yet clear
Registered Holders
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POLYPEPTIDE LABORATORIES INC
Active
United States
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BACHEM AMERICAS INC
Active
United States
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TEVA PHARMACEUTICAL INDUSTRIES LTD
Inactive
France
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