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Home > News > Food Industry News > The study revealed the mechanism by which nucleases enhance the probiotic effect of Bacillus velez T23

The study revealed the mechanism by which nucleases enhance the probiotic effect of Bacillus velez T23

foodmate 2023-01-03

Recently, the aquatic microbiology and feed innovation team of the Feed Research Institute of the Chinese Academy of Agricultural Sciences showed that after nuclease treatment, the probiotic Bacillus velezensis T23 can reduce the lipid metabolism of zebrafish liver induced by high-fat feed The level of disturbances, intestinal damage, and inflammation in the body reveal the mechanism of action. The findings were published in Aquaculture.
 
Metabolic diseases caused by high-fat feed are a major problem in aquaculture today. The addition of nuclease-treated Bacillus velezensis T23 solid fermentation broth (T23 N) to high-fat feed was found to enhance zebrafish non-specific immunity and reduce liver lipid metabolism disorders, intestinal damage and inflammation levels caused by high-fat feed. The researchers further analyzed the intestinal flora of zebrafish and found that feeding nuclease treatment of T23 could improve the structure of intestinal flora, reduce the richness and diversity of intestinal flora in zebrafish, and significantly increase the abundance of Fusobacteriota and Cetobacterium. In addition, nuclease treatment enhances T23's ability to alleviate lipid metabolism disorders and inflammation caused by high-fat feed. In this study, the mechanism of nuclease-enhancing the probiotic effect of Bacillus velezensis T23 was analyzed, which provided theoretical support for the application of nucleases in feed.
 
This research was supported by the National Natural Science Foundation of China (NSFC32172991, 32061133004, 31925038, 31972807, 31872584) and Shaanxi Innovation Capacity Support Program (2018TD-021).

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