The Oral GLP-1 Cage Match: Orforglipron vs Rybelsus
Eli Lilly’s once-daily oral GLP-1, orforglipron, outperformed Novo Nordisk’s oral semaglutide (Rybelsus) in a head-to-head diabetes study, reinforcing Lilly’s bid to lead in pills as well as injectables; the result extends the company’s incretin edge beyond Mounjaro/Zepbound and signals fiercer competition for oral market share as capacity and adherence dynamics shift toward convenient formulations.
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