A major raw material in the bone and joint health market-non-denatured type II collagen

When it comes to bone and joint health, in addition to glucosamine and chondroitin sulfate, there is also a family of raw materials, talented people who not only care for the tenderness of the skin, but also care about the health of the joints, it is the famous collagen-collagen.

Global sales data of joint supplements tell us that new ingredients including non-denatured type II Collagen are becoming more and more popular with consumers.

Collagen is a structural protein of the extracellular matrix, which contains one or several triple helix structure regions composed of α-chains. There are more than 20 different types of collagen that have been discovered.

Simply put, type I and type III collagen are mainly found in connective tissues such as skin blood vessels, and type II collagen (Collagen type II, CII) is mainly produced by cartilage cells and has a dense fibrous structure. It is mostly found in bones, joints, and joints. Tissues such as tendons are the most important organic components in the cartilage matrix. They are the characteristic proteins of cartilage tissue. They can be closely combined with polysaccharides to make cartilage flexible, capable of absorbing shocks and bearing loads.

According to whether it maintains a complete triple helix structure, type II collagen can be divided into denatured type II collagen and undenatured type II collagen. Among them:

Denatured type II collagen: The triple helix structure is damaged to varying degrees, and its biocompatibility and immune activity will be greatly reduced. And if the triple helix structure is severely damaged, even affecting the breakage of peptide bonds, type II collagen will completely lose its binding properties with polysaccharides and other molecules, lose its biological activity, and be absorbed and utilized by the body like ordinary proteins.

Non-denatured type II collagen: maintains a complete triple helix structure, has good biocompatibility, low antigenicity, and the appropriate concentration of non-denatured type II collagen induces human immune tolerance, which can prevent or relieve osteoarthritis, Rheumatoid arthritis condition.

Non-denatured type II collagen is effective at a dose of 40 mg/day, while hydrolyzed collagen requires 10 g/day [2,3]. Numerous studies have shown that non-denatured type II collagen can significantly improve the bones and joints of animals and humans.

Lugo et al. used a randomized, double-blind, placebo-controlled study on the effect of non-denatured type II collagen in improving knee joint extension and comfort after exercise in healthy adults. The results showed that non-denatured type II collagen is well tolerated and can Significantly improve the extension and comfort of the knee joint of healthy adults after exercise, and significantly reduce the recovery time and pain after exercise.

Lugo James et al. used a randomized double-blind multi-center method and used WOMAC, VAS and Lequesne methods to evaluate the effect of chicken breast cartilage non-denatured type II collagen on arthritis. The experimental results showed that the WOMAC value of the non-denatured type II collagen group was compared with placebo. Compared with the amino sugar + cartilage sulfate group, the curative effect was significantly better than that of the placebo group and the amino sugar + chondroitin sulfate group, and the pain, morning stiffness and physiological function improvement effect were very obvious.

Crowley et al. studied the effect of non-denatured type II collagen in improving osteoarthritis and compared its effects with Glucosamine and chondroitin sulfate. The results showed that non-denatured type II collagen (40 mg/day for 90 days) is resistant to It is well receptive and non-denatured type II collagen is more effective for patients with moderate to severe knee osteoarthritis.

Bagi et al. studied the effect of chicken non-denatured type II collagen on osteoarthritis model rats after meniscus resection, and found that the daily clinically relevant dose of non-denatured type II collagen immediately after injury can improve the mechanical function of the injured knee joint. To prevent excessive deterioration of articular cartilage, it is determined that the undenatured type II natural chicken collagen has the function of preventing excessive deterioration of articular cartilage in osteoarthritis model rats.

Bagchi used the ELISA method to confirm that UC-II® non-denatured type II collagen, due to its structure and glycosylated bioactive epitopes, can act on the small intestinal immune system after passing through the digestive tract, and treat bones and joints through oral immune mechanisms. Protect it.

According to the relevant opinion of the National Health and Family Planning Commission in 2016: Non-denatured type II collagen (also renamed cartilage powder containing type II collagen) uses chicken breast cartilage as raw material, after washing, disinfection, and crushing, Potassium Chloride is added, and under low temperature conditions The collagen-containing cartilage powder obtained after drying can be used for the production and operation of ordinary food. The product quality indicators are implemented in accordance with corporate standards, and the health and safety indicators are implemented in accordance with GB2762, GB29921.

With the increasing aging of our country, the number of patients with osteoarthritis will increase significantly, and the demand for bone and joint health will gradually become younger, and there is an urgent need for functional raw materials for bone and joint health. UC-II® helps to strengthen joint health, relieve joint pain, promote joint flexibility, and improve the quality of life and physical and mental health of patients with osteoarthritis. It will surely become a revolutionary functional raw material for bone and joint health, and has a broad market development prospect.