This product is a lincosamide antibiotic that mainly binds to the 50S subunit bacterial ribosome, inhibits early bacterial protein synthesis, removes the A protein and villi coat on the bacterial surface, and makes it easy to be phagocytosed and killed. In vitro tests show that clindamycin is active against the following microorganisms: 1. Aerobic Gram-positive cocci: Staphylococcus aureus and Staphylococcus epidermidis (both penicillinase-producing and non-penicillinase-producing strains), Streptococci (except Enterococcus faecalis), and Pneumococci. 2. Anaerobic Gram-negative rods: Bacteroides (including Bacteroides fragilis and melanin-producing Bacteroides) and Fusobacterium. 3. Anaerobic Gram-positive non-spore-producing rods: Propionibacterium, Eubacterium, and Actinomyces. 4. Anaerobic and microaerophilic Gram-positive rods: Peptococcus, microaerophilic Streptococcus, and Peptostreptococcus.

This product is a derivative of clindamycin. It is hydrolyzed by esterase in the body to form clindamycin and exert its antibacterial activity. Clindamycin has good antibacterial effects on Gram-positive cocci and anaerobic infections by inhibiting the synthesis of bacterial proteins. It has good antibacterial effects on Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, etc., and is moderately sensitive to Haemophilus influenzae and Neisseria gonorrhoeae. Some erythromycin-resistant Staphylococcus aureus and Staphylococcus epidermidis are still sensitive to this product. It has good antibacterial effects on both Gram-negative and Gram-positive anaerobic bacteria, among which the MIC50 and MIC90 for Bacteroides fragilis are 0.062 and 0.5 mg/ml respectively, and the MIC50 and MIC90 for Peptostreptococcus are 0.125 and 4 mg/ml respectively.

It has strong anti-inflammatory, liver cell membrane protection and liver function improvement effects. It can reduce the increase of serum alanine aminotransferase and aspartate aminotransferase caused by carbon tetrachloride, thioacetamide and D-galactosamine, reduce the morphological damage of D-galactosamine to the liver and improve the chronic damage of immune factors to the liver morphology.

Omeprazole is a racemic mixture of a pair of active optical enantiomers. It reduces gastric acid secretion through a highly targeted mechanism of action and is a special inhibitor of the acid pump in gastric parietal cells. This product acts rapidly, and a once-daily dose can reversibly inhibit gastric acid secretion. Omeprazole is a weakly alkaline substance that is concentrated and converted into active substances in the highly acidic environment of the tubules in the gastric parietal cells, inhibiting H, K-ATPase (proton pump). This inhibitory effect on the final step of gastric acid formation is dose-related and highly inhibits basal gastric acid secretion and irritant gastric acid secretion, but is unrelated to irritants. Intravenous administration of omeprazole in humans inhibits gastric acid secretion in a dose-related manner. Helicobacter pylori is associated with acid peptic diseases, including duodenal ulcers and gastric ulcers, with 95% and 70% of duodenal ulcers and gastric ulcers being associated with Helicobacter pylori infection, respectively. Helicobacter pylori is the main cause of gastritis. Helicobacter pylori and gastric acid are the main causes of peptic ulcers. Omeprazole combined with antibiotics can eradicate Helicobacter pylori, which is associated with rapid relief of symptoms, high rates of gastric mucosal repair, and long-term remission of peptic ulcer disease, thereby reducing complications such as gastrointestinal bleeding and the need for long-term treatment with anti-acid drugs.

This product is a non-peptide endothelin receptor antagonist, which can antagonize endothelin-induced vasoconstriction, blood pressure increase and vascular smooth muscle cell proliferation, reduce vascular endothelial damage; increase NO synthesis, relax vascular smooth muscle; inhibit platelet aggregation, anti-coagulation, and improve blood rheology characteristics. This product can also inhibit cholesterol synthesis, lower blood lipids, scavenge free radicals, prevent lipid peroxidation damage; affect complement, enhance immune function, and have certain analgesic and antispasmodic effects.