Dihydropyridine calcium antagonists can selectively inhibit the transmembrane transport of calcium ions into myocardial cells and smooth muscle cells, and inhibit the release of calcium ions from intracellular pools without changing the plasma calcium ion concentration. Pharmacological effects include: 1. It can simultaneously dilate the coronary arteries in the normal blood supply area and the ischemic area, antagonize spontaneous or ergonovine-induced coronary artery spasm, increase the delivery of myocardial oxygen in patients with coronary artery spasm, and relieve and prevent coronary artery spasm; 2. It can inhibit myocardial contraction, reduce myocardial metabolism, and reduce myocardial oxygen consumption; 3. It can dilate peripheral resistance vessels, reduce peripheral resistance, reduce systolic and diastolic blood pressure, and reduce cardiac afterload; 4. It can delay the sinus node function and atrioventricular conduction of the isolated heart; electrophysiological studies of whole animals and humans have not found that this product has the effect of delaying atrioventricular conduction, prolonging the recovery time of the sinus node, and slowing down the sinus node rate.

An important component of coenzymes required for sugar metabolism

Important coenzyme component required for tissue respiration

Component of coenzymes I and II, essential for lipid metabolism and oxidation of tissue respiration

A cofactor for many enzymes, involved in the metabolism of amino acids and fats

Component of coenzyme A, involved in the metabolism of sugar, fat and protein

This product is a broad-spectrum antifungal drug. It interferes with the activity of cytochrome P450, inhibits the biosynthesis of ergosterol in fungal cell membranes, damages fungal cells and changes their permeability, leading to leakage of intracellular substances; inhibits the biosynthesis of triglycerides and phospholipids in fungi, inhibits the activity of oxidases and peroxidases, causes accumulation of hydrogen peroxide in cells, leads to cell submicrostructure degeneration and cell necrosis. For Candida albicans, it can inhibit the process of transformation from spores to invasive hyphae.

It has the anti-inflammatory, anti-allergic and vasoconstrictive effects of topical glucocorticoids.

It has antibacterial effect on Staphylococcus (methicillin-sensitive strains) and Corynebacterium.

In acute toxicity experiments, the LD50 in mice and rats was greater than 4000 mg/Kg. In subacute toxicity experiments, Wistar male and female rats were given 40 mg, 200 mg and 1000 mg/Kg per day for 5 weeks, and male and female rabbits were given 6 mg, 60 mg and 600 mg/Kg per day for 23 consecutive days. There were no special changes in the blood, urine and morphological observations of the test animals. In chronic toxicity experiments, Wistar male and female rats were given 6 mg, 60 mg and 600 mg/Kg per day for 26 consecutive weeks. There were no special changes in the general state, blood and urine examinations, and morphological observations of the test animals.