Cefaclor Granules

This product is a broad-spectrum semi-synthetic cephalosporin antibiotic. Its activity against penicillinase-producing Staphylococcus aureus, group A hemolytic streptococci, viridans streptococci and Staphylococcus epidermidis is the same as that of cefadroxil, and its antibacterial effect against non-enzyme-producing Staphylococcus aureus and pneumococci is 2 to 4 times stronger than that of cefadroxil. Its activity against Gram-negative bacilli, including Escherichia coli and Klebsiella pneumoniae, is stronger than that of cefadroxil, and is similar to that of cefadroxil. Its activity against Proteus mirabilis, Salmonella and Shigella is stronger than that of cefadroxil. 2.9 to 8 mg/L of this product can inhibit all Haemophilus influenzae, including strains resistant to ampicillin. Moraxella catarrhalis and Neisseria gonorrhoeae are very sensitive to this product. Indole-positive Proteus, Serratia, Acinetobacter and Pseudomonas aeruginosa are all resistant to this product. The mechanism of action of this product is to inhibit the synthesis of bacterial cell walls.

The main chemical component is cefaclor: (6R,7R)-7-[(R)-2-amino-2-phenylacetylamino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate

This product is a granule with added flavoring agent.

This product is mainly suitable for respiratory system, urinary system, ENT, skin and soft tissue infections caused by sensitive bacteria.

Oral administration. Adults: 0.25g once, 3 times a day. For patients with severe infection, the dose can be doubled, but the total amount per day should not exceed 4g. Or follow the doctor's advice. Children: 20-40mg/kg per day, divided into 3 doses, but the total amount per day should not exceed 1g.

1. Common gastrointestinal reactions: soft stools, diarrhea, stomach discomfort, loss of appetite, nausea, vomiting, heating, etc. 2. Serum sickness-like reactions are more common than other antibiotics, especially in children, with typical symptoms including skin reactions and joint pain. 3. Allergic reactions: rash, urticaria, eosinophilia, vulvar itching, etc. 4. Others: mild increase in serum aminotransferase, urea nitrogen and creatinine, proteinuria, cystic urine, etc.

Patients who are allergic to this product or other cephalosporins are contraindicated.

Precautions for children: The efficacy and safety of this product for infants under one month have not yet been established. Precautions during pregnancy and lactation: 1. Pregnant women: Multiple reproductive studies have been conducted on mice and rats, with doses as high as 1.2 times the human dose, and the dose studied on ferrets is three times the maximum human dose. The results showed that there was no evidence that cefaclor impaired fertility or endangered the fetus. However, there are no sufficient strictly controlled clinical studies on pregnant women. Because animal reproductive studies cannot fully predict human responses, pregnant women should not use this product unless it is absolutely necessary. 2. Childbirth: The effect of cefaclor on childbirth is still unclear. 3. Lactating women: After a lactating woman takes a single oral dose of 500 mg of cefaclor, a small amount of cefaclor can be detected in breast milk. The average levels at 2, 3, 4 and 5 hours after taking the drug are 0.18, 0.20, 0.21 and 0.16 mg/L, respectively. Trace amounts were detected in the first hour. Note for the elderly: According to literature reports, compared with healthy adult subjects under 45 years old, 40-45% of healthy elderly subjects (over 65 years old) who took 750 mg of cefaclor alone had high AUC and 20% of patients had low renal clearance.

The combined use of strong diuretics such as furosemide, ethacrynic acid, bumetanide, antineoplastic drugs such as carmustine, streptozocin, and nephrotoxic drugs such as aminoglycoside antibiotics with this product may increase nephrotoxicity. Clavulanic acid can enhance the antibacterial activity of this product against certain Gram-negative bacteria that are resistant to this product due to the production of beta-lactamase. Oral administration of probenecid can delay the excretion of this product.

Keep away from light, seal tightly, and store in a cool, dark and dry place.

Calculate as C15H14ClN3O4S 0.1g

24 months

Shandong Lukang Pharmaceutical Co., Ltd.

• Founded in:

  1993-02-15

• Address:

  No. 88, Deyuan Road, Jining High-tech Zone, Shandong Province

• Tax NO.:

  913700001659297311

• Registered Funds:

  880.229735 yuan

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