Foscarnet Sodium Chloride Injection

This product is a virus inhibitor. It can non-competitively block the phosphate binding site of viral DNA polymerase, prevent the separation of pyrophosphate from triphosphonate deoxynucleoside and the extension of viral DNA chain. This product does not rely on the activation of viral thymidine kinase in cells, and viral replication can still be restored after discontinuation of this product. In vitro tests show that this product can inhibit the replication of all herpes viruses, including herpes simplex (HSV-1 and HSV-2), herpes zoster, EB virus, human herpes virus-6 and cytomegalovirus. This product can also non-competitively inhibit HIV reverse transcriptase and hepatitis B virus DNA polymerase.

The main ingredient of this product is: Sodium foscarnet. Its chemical name is: Trisodium foscarnet hexahydrate.

This product is a colorless clear liquid.

This product is mainly used to treat cytomegalovirus retinitis in immunocompromised patients (such as AIDS patients). It can also be used to treat skin and mucosal herpes simplex virus infection or herpes zoster virus infection in immunocompromised patients (such as HIV-infected patients) who are resistant to acyclovir.

Intravenous drip. Medication for induction period of cytomegalovirus retinitis: once every 8 hours, drip 60mg/kg according to body weight, drip for more than 1 hour with an infusion pump, for 14 to 21 consecutive days, depending on the effect after treatment, or 90mg/kg according to body weight, once every 12 hours. The dosage for patients with impaired renal function should be adjusted according to creatinine clearance. The dosage is as follows: Creatinine clearance (ml/min) Dose every 8 hours (mg/kg) Creatinine clearance (ml/min) Dose every 8 hours (mg/kg) ≥9660543590574832845342287849362572463021664224186039 Medication for maintenance period: 90mg/kg according to body weight, once a day

1. Renal function impairment is the most important adverse reaction of this product, which can cause acute tubular necrosis, nephrogenic diabetes insipidus and sodium foscarnet crystalluria. There may also be hypocalcemia or hypercalcemia, high or low blood phosphorus, hypokalemia, etc. 2. Central nervous system symptoms: headache, tremor, irritability, hallucinations, convulsions, etc., which may be related to electrolyte disorders. 3. Blood system: anemia, granulocytopenia, thrombocytopenia, etc. 4. Metabolic and nutritional disorders: hyponatremia and lower limb edema, elevated lactate dehydrogenase, alkaline phosphatase or amylase. 5. Cardiovascular system: ECG abnormalities, hypertension or hypotension, ventricular arrhythmias. 6. Other reactions: nausea, vomiting, loss of appetite, abdominal pain, fever, abnormal liver function and phlebitis, etc.

It is contraindicated for patients who are allergic to this product or whose creatinine clearance is lower than 0.4ml/min/kg.

Precautions for children: There is no experience of using this product for children. Precautions for pregnancy and lactation: Pregnant women should not use this product unless necessary. Lactating women should stop breastfeeding while using this product. Precautions for the elderly: No such test has been conducted and there is no reliable reference literature.

1. This product may increase renal toxicity when used in combination with other nephrotoxic drugs such as aminoglycoside antibiotics and amphotericin B. 2. When used in combination with pentamidine injection (intravenous), there may be a risk of anemia. It may cause hypocalcemia, hypomagnesemia and renal toxicity. 3. When used in combination with zivdodine, anemia may be aggravated, but no aggravation of bone marrow suppression has been found.

Keep away from light and store in a sealed container.

500 ml: 6.0 g

24 months

CHIA TAI Tianqing Pharmaceutical Group Co., Ltd.

• Founded in:

  1997-04-16

• Address:

  No. 369, Yuzhou South Road, Lianyungang City, Jiangsu Province

• Tax NO.:

  91320000608398264T

• Registered Funds:

  890 million yuan

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