Norgestrel Ethinyl Estradiol Tablets

Ethinyl estradiol (ethinyl estradiol cyclopentyl ether) is a long-acting estrogen. After oral administration, it is absorbed through the gastrointestinal tract and stored in adipose tissue. It slowly releases ethinyl estradiol, inhibiting ovarian ovulation by inhibiting the hypothalamus-pituitary-ovarian axis, achieving a long-term contraceptive effect. Progesterone combined with it has a synergistic effect on inhibiting ovulation and can transform the endometrium, presenting a secretory phenomenon, leading to withdrawal bleeding, and forming a cyclical change. Taking the medicine once a month, the contraceptive rate can reach more than 98%.

This product is a compound preparation, each tablet containing 6 mg of levonorgestrel and 3 mg of ethinyl estradiol.

This product is a sugar-coated tablet or a film-coated tablet.

Healthy women of childbearing age should avoid using it, but it is suitable for those who are willing to continue taking contraceptive pills.

For oral administration, take the medicine once after lunch on the 5th day starting from the day of menstruation, and take the second time after an interval of 20 days, or take 1 tablet after lunch on the 5th or 10th day of menstruation. Thereafter, the second dose will be used as the monthly medication date. Take one tablet per month. Generally, withdrawal bleeding will occur 6 to 12 days after taking the medicine.

1. Early pregnancy reaction, similar to short-acting oral contraceptives, but more severe. The first few cycles of taking the medicine are more severe, and the reaction usually occurs 8 to 12 hours after taking the medicine. Therefore, taking the medicine after lunch so that the reaction peaks during deep sleep can reduce it. 2. Increased vaginal discharge: the most common side effect of long-acting oral contraceptives. It usually occurs after 3 to 6 cycles. 3. A few people experience excessive menstruation or amenorrhea. 4. Other symptoms include stomach pain, edema, breast tenderness, headache, etc.

It is contraindicated for patients with uterine fibroids, breast lumps, liver and kidney dysfunction, cardiovascular disease, history of thrombosis, hypertension, diabetes, hyperthyroidism, mental illness or depression, and hyperlipidemia.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.

1. Drugs that affect contraceptive effects: Antibiotics inhibit the growth of intestinal bacteria, reduce the decomposition of hormone conjugates, and reduce enterohepatic circulation; drugs that induce liver enzymes such as rifampicin, hypnotics and anticonvulsants, antipyretics and analgesics; tricyclic antidepressants compete with this product in the liver for common metabolic enzymes. 2. Drugs that are affected by the combined use of contraceptives: The antihypertensive effect of antihypertensive drugs is reduced; the effect of anticoagulants is reduced; the efficacy of hypoglycemic drugs (such as insulin and oral hypoglycemic drugs) in controlling diabetes is reduced; the effect of tricyclic antidepressants is enhanced.

Sealed storage

Compound

24 months

China Resources Zizhu Pharmaceutical Co., Ltd.

• Founded in:

  1980-11-26

• Address:

  Building 18, No. 27 Chaoyang North Road, Chaoyang District, Beijing

• Tax NO.:

  91110000101939631P

• Registered Funds:

  660.6396 million yuan

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