Mezlocillin Sodium for Injection

This product is a semi-synthetic penicillin antibiotic. It has an antibacterial effect on Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Proteus, Enterobacter, Citrobacter, Serratia, Acinetobacter, and Gram-positive cocci sensitive to penicillin. It has a bactericidal effect in large doses. Its antibacterial activity against Escherichia coli, Enterobacter, Klebsiella pneumoniae, Citrobacter, Serratia, and Acinetobacter is stronger than that of carbenicillin and ampicillin; its antibacterial activity against indole-positive Proteus and Pseudomonas aeruginosa is stronger than that of carbenicillin and sulbenicillin; its antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus is similar to that of carbenicillin, and its antibacterial activity against Streptococcus faecalis is superior to that of carbenicillin and sulbenicillin. It has a good antibacterial effect against most anaerobic bacteria such as Bacteroides fragilis. This product has good in vitro test results.

The main ingredient of this product is mezlocillin sodium, and its chemical name is (2S, 5R, 6R)-3,3-dimethyl-6-[(R)-2[3-(methylsulfonyl)-2-oxo-1-imidazolidinecarboxamido]-2-phenylacetylamino]-7-oxo-4-thia-1-azabicyclo[3.2.0]-heptane-2-carboxylic acid sodium salt.

This product is white or off-white powder or crystal or loose lump.

It is used for infections of the respiratory system, urinary system, digestive system, gynecological system and reproductive organs caused by sensitive strains of Gram-negative bacilli such as Escherichia coli, Enterobacter, Proteus, such as sepsis, purulent meningitis, peritonitis, osteomyelitis, skin and soft tissue infections, and eye, ear, nose and throat infections.

Intramuscular injection, intravenous injection or intravenous drip. For intramuscular injection, add sterile injection water to dissolve before use. For intravenous injection, usually add 5% glucose sodium chloride injection or 5%-10% glucose injection to dissolve before use. Adults take 2-6g a day, which can be increased to 8-12g for severe infection, and up to 15g. For children, 0.1-0.2g/kg per day based on body weight, which can be increased to 0.3g/kg for severe infection; intramuscular injection 2-4 times a day, intravenous drip once every 6-8 hours as needed, the dosage depends on the condition, and severe cases can be injected intravenously once every 4-6 hours.

The main adverse reactions are: anorexia, nausea, vomiting, diarrhea, local pain after intramuscular injection and rash, which mostly occur during the administration process. Most of them are mild and do not affect the continued use of the drug. In severe cases, the above symptoms are rapidly alleviated or disappear after stopping the drug. In a few cases, serum aminotransferase, alkaline phosphatase and transient increase in eosinophils may occur. Neutropenia and hypokalemia are extremely rare. No serious reactions such as changes in renal function and blood electrolyte disorders were observed.

It is contraindicated for patients who are allergic to penicillin antibiotics.

Precautions for children: Precautions for pregnancy and lactation: This product can enter the fetal blood circulation through the placenta and a small amount is secreted with breast milk. Although there are no reports of serious problems with the use of this product by lactating women, pregnant women and lactating women should still weigh the pros and cons, because its use can sensitize infants and cause diarrhea, rash, Candida infection, etc. Precautions for the elderly: Elderly patients have impaired renal function and need to adjust the dosage.

1 Aspirin, indomethacin, phenylbutazone, and sulfonamides can reduce the excretion of this product in the renal tubules, thereby increasing the blood concentration of this product, prolonging the blood elimination half-life (t1/2), and the toxicity may also increase. 2 When this product is used in combination with allopurinol, the incidence of rash increases significantly, so the combination should be avoided. 3 This product should not be used in combination with acetaldehyde dehydrogenase inhibitors such as disulfiram. 4 When this product is used in combination with chloramphenicol for bacterial meningitis, the incidence of long-term sequelae is higher than when either is used alone. 5 This product can stimulate estrogen metabolism or reduce its enterohepatic circulation, thereby reducing the effectiveness of oral contraceptives. 6 Antibiotics such as chloramphenicol, erythromycin, tetracyclines and antibacterial drugs such as sulfonamides can interfere with the bactericidal activity of this product, so it is not suitable to be used in combination with this product, especially in the treatment of meningitis or severe cases that urgently need bactericidal drugs.

Seal and store in a dry, cool and dark place. Validity period: two years

3.0g

Shanxi Shuangyan Pharmaceutical Co., Ltd.

• Founded in:

  2004-06-18

• Address:

  Datong Development Zone Pharmaceutical Industrial Park

• Tax NO.:

  91140200762481795D

• Registered Funds:

  250 million yuan

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