Nicardipine Hydrochloride and Glucose Injection

This product inhibits the transmembrane calcium ion influx of myocardial and vascular smooth muscle without changing the blood calcium concentration. Its effect on vascular smooth muscle is better than that on myocardium, so its vascular selectivity is relatively strong. In animal experiments, this product selectively dilates coronary vascular smooth muscle. The blood concentration when this effect occurs does not produce negative inotropic effect (myocardium), and has little effect on heart rhythm and cardiac contractility. In the human body, this product reduces peripheral vascular resistance. This effect is greater in patients with hypertension than in those with normal blood pressure, and there will be a reflex increase in heart rate when blood pressure is lowered. This product increases cardiac ejection fraction and cardiac output, while the left ventricular end-diastolic pressure does not change much. It can reduce myocardial oxygen consumption and total peripheral resistance, and can also increase coronary collateral circulation, thereby increasing coronary blood flow.

The main ingredient is nicardipine hydrochloride. The auxiliary materials are glucose and water for injection.

Colorless transparent liquid

Treat hypertensive emergencies and emergency treatment of abnormally high blood pressure during surgery.

First aid for abnormally high blood pressure during surgery: First, drip 2-10 μg/kg (body weight) per minute intravenously. After the blood pressure drops to the target value, adjust the drip rate while monitoring the blood pressure. If it is necessary to quickly lower the blood pressure, give nicardipine hydrochloride at 10-30 μg/kg (body weight) per minute intravenously. Hypertensive emergency: First, drip 0.5-6 μg/kg (body weight) per minute intravenously. After the blood pressure drops to the target value, adjust the drip rate while monitoring the blood pressure.

The more common symptoms are swollen feet, dizziness, headache, and flushed face, all of which are the result of vasodilation. Less common symptoms are palpitations, tachycardia, and worsening angina pectoris, which are often the result of reflex tachycardia and can be corrected by reducing the dose or adding beta-blockers. Less common symptoms include nausea, dry mouth, constipation, fatigue, and rash.

Allergic reaction to this product. Severe aortic stenosis.

Precautions for children: The safety of this product in children is still lacking. Precautions for pregnancy and lactation: 1. There is still a lack of well-controlled studies on the use of this product in pregnant women. Some animal experiments have adverse effects, so pregnant women must weigh the pros and cons when using it. 2. This product may be excreted into breast milk, so the use of lactating women must weigh the pros and cons. Precautions for the elderly: The pharmacokinetic study of this product in the elderly and young and middle-aged people did not find any difference, so the use of this product in the elderly is the same as that in young and middle-aged people. When using this product in the elderly, it is advisable to start with a low dose (0.5μg/(kg·min)).

1 This product is well tolerated when used in combination with beta-blockers. 2 This product increases blood concentrations when used in combination with cimetidine. 3 This product does not increase blood concentrations of digoxin when used in combination with digoxin, but digoxin blood concentrations must be measured. 4 When this product is used in combination with cyclosporine, cyclosporine blood concentrations increase. 5 In vitro, therapeutic concentrations of furosemide, propranolol, dipyridamole, warfarin, quinidine, and naproxen added to human plasma do not change the protein binding rate of this product.

Store tightly sealed.

100ml: Nicardipine hydrochloride 10mg and glucose 5.5g

18 months

Jinzhou Jiutai Pharmaceutical Co., Ltd.

• Founded in:

  1998-09-02

• Address:

  No. 41, Tai'anli, Taihe District, Jinzhou City, Liaoning Province

• Tax NO.:

  91210700242034190P

• Registered Funds:

  40.986462 million yuan

• Website:

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