Erythromycin suppositories

1. This product belongs to the macrolide antibiotics. It has antibacterial activity against Staphylococcus (except methicillin-resistant strains), various groups of streptococci and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Bordetella pertussis, etc. are also sensitive to this product. 2. This product also has antibacterial effects on various anaerobic bacteria except Bacteroides fragilis and Fusobacterium. It also has inhibitory effects on Legionella, Campylobacter fetus, certain spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia. 3. This product can penetrate the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor site ("P" site), blocking the transfer RNA (t-RNA) from binding to the "P" site, and also blocking the displacement of the polypeptide chain from the acceptor site ("A" site) to the "P" site, thereby inhibiting bacterial protein synthesis.

The main ingredient of this product and its chemical name: erythromycin. Its chemical structure is: Molecular formula: C37H67NO13 Molecular weight: 733.94

This product is a conical milky white suppository.

1. This product is used as an alternative drug for the following infections in patients allergic to penicillin: acute tonsillitis, acute pharyngitis, sinusitis caused by hemolytic streptococci, pneumococcus, etc.; scarlet fever and cellulitis caused by hemolytic streptococci; diphtheria and diphtheria carriers; gas gangrene, anthrax, tetanus, actinomycosis; syphilis; listeria, etc. 2. Legionnaires' disease. 3. Chlamydia and mycoplasma pneumonia. 4. Urinary and reproductive system infections caused by chlamydia and mycoplasma. 5. Chlamydia trachomatis conjunctivitis. 6. Neisseria gonorrhoeae infection. 7. Oral infection caused by anaerobic bacteria. 8. Campylobacter jejuni enteritis. 9. Whooping cough, etc.

Rectal administration. 2 tablets at a time, twice a day. Usage: Take out the suppository and insert it into the anus 2 cm deep with the medicine delivery device. You can also wear a finger cot and deliver the medicine with your fingers.

1. Hepatotoxicity is rare, and patients may experience fatigue, fever, abnormal liver function, and occasionally jaundice. 2. Allergic reactions are manifested as drug fever, rash, eosinophilia, etc., with an incidence of about 0.5% to 1%. 3. Others, occasionally arrhythmia, oral or vaginal candidiasis.

1. It is contraindicated for patients who are allergic to erythromycin. 2. It is contraindicated for patients with diarrhea. 3. It is contraindicated for patients with severe liver dysfunction.

Precautions for children: 100,000 units (each containing 0.1 g of erythromycin) suppositories should be used. Children should use 20 to 30 mg per kilogram of body weight per day or follow the doctor's advice. Reference table for dosage and usage of children's medication Daily reference dosage for children's weight Recommended usage Remarks 5kg 1-1.5 tablets Half a tablet each time, 2-3 times a day Note: Smooth 10kg 2-3 tablets 1 tablet each time, 2-3 times a day 15kg or more 3-4 tablets 1 tablet each time, 3-4 times a day Precautions for pregnancy and lactation: 1. Erythromycin can enter the fetal circulation through the placenta, and the concentration is generally not high. There are no reports on the effects on the fetus in the literature, but pregnant women should still weigh the pros and cons when using it. 2. A considerable amount of erythromycin enters breast milk, and the pros and cons should be considered when using it in lactating women. Precautions for the elderly: Not yet clear.

1. Erythromycin can inhibit the metabolism of antiepileptic drugs such as carbamazepine and valproic acid, resulting in increased blood concentrations of the latter and toxic reactions. Erythromycin combined with fentanyl can inhibit the metabolism of the latter and prolong its duration of action. Erythromycin combined with antihistamines such as astemizole or terfenadine can increase cardiac toxicity, and combined with cyclosporine can increase the latter's blood concentration and produce nephrotoxicity. 2. Erythromycin has an antagonistic effect on chloramphenicol and lincomycin, and it is not recommended to use them together. 3. This product is an antibacterial agent that can interfere with the bactericidal effect of penicillin. Therefore, when a rapid bactericidal effect is required, such as the treatment of meningitis, the two should not be used together. 4. Patients who have been taking warfarin for a long time may have a prolonged prothrombin time when using erythromycin, thereby increasing the risk of bleeding. Elderly patients should pay special attention. When the two must be used together, the dose of warfarin should be appropriately adjusted and the prothrombin time should be closely observed. 5. Except for dihydroxypropylphylline, the co-administration of erythromycin and xanthines can reduce the hepatic clearance of aminophylline, leading to increased serum aminophylline concentrations and (or) increased toxic reactions. This phenomenon is more likely to occur after 6 days of co-administration, and the reduction in aminophylline clearance is proportional to the erythromycin serum peak. Therefore, the dose of xanthines should be adjusted during and after the co-administration course. 6. The co-administration of erythromycin with other hepatotoxic drugs may enhance hepatotoxicity. 7. The co-administration of high-dose erythromycin with ototoxic drugs, especially in patients with renal impairment, may increase ototoxicity. 8. When used in combination with lovastatin, it can inhibit the latter's metabolism and increase its blood concentration, which may cause rhabdomyolysis. When used in combination with midazolam or triazolam, it can reduce the clearance of both and enhance their effects.

Seal tightly and store in a cool place (not exceeding 20°C).

0.1 g (100,000 units)

24 months

Jinzhou Jiutai Pharmaceutical Co., Ltd.

• Founded in:

  1998-09-02

• Address:

  No. 41, Tai'anli, Taihe District, Jinzhou City, Liaoning Province

• Tax NO.:

  91210700242034190P

• Registered Funds:

  40.986462 million yuan

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