Propafenone Hydrochloride Tablets

1 This product belongs to the class Ic (i.e., it directly acts on the cell membrane) antiarrhythmic drug. The experimental results of isolated animal myocardium indicate that 0.5-1ug/min can reduce the depolarization effect during contraction, thereby prolonging conduction, slightly prolonging the duration of action potential and the effective refractory period, and can increase the threshold potential of myocardial cells, significantly reducing the spontaneous excitability of the myocardium. It acts on both the atria and ventricles (mainly affecting the Purkinje fibers, with less effect on the myocardium), and also on the formation and conduction of excitement. Clinical data show that therapeutic doses (300mg for oral administration and 30mg for intravenous injection) can reduce the irritability of the myocardium, with a long-lasting effect, increasing PQ and QRS, and prolonging the effective refractory period of the atria and atrioventricular node. It has an effect on various types of experimental arrhythmias.

The main ingredient and chemical name of this product are: 3-phenyl-1-[2-[3-(propylamino)-2-hydroxypropoxy]-phenyl]-1-propanone hydrochloride

This product is white or off-white tablets.

Used for paroxysmal ventricular tachycardia and supraventricular tachycardia (including those with preexcitation syndrome).

Oral: 100-200 mg per time, 3-4 times a day. Therapeutic dose: 300-900 mg per day, divided into 4-6 doses. Maintenance dose: 300-600 mg per day, divided into 2-4 doses. Due to its local anesthetic effect, it is advisable to swallow it with drinks or food after meals and do not chew it.

1. There are fewer adverse reactions, the main ones are dry mouth and numbness of the tongue and lips, which may be due to its local anesthetic effect. In addition, early adverse reactions include headache, dizziness, and glare, followed by gastrointestinal disorders such as nausea, vomiting, and constipation. There are also symptoms of atrioventricular block. There are two reports of cholestatic liver damage after two weeks of continuous use. The activity of each enzyme returned to normal 2 to 4 weeks after stopping the drug. It is believed that this pathological change is due to allergic reactions and individual factors. 2. During the trial, no damage to the lungs, liver, and hematopoietic system was observed. A small number of patients experienced mild reactions such as dry mouth, headache, dizziness, and gastrointestinal discomfort mentioned above. Generally, the symptoms disappeared after stopping the drug or reducing the dosage. There are reports of atrioventricular conduction block and Q-T in individual patients.

It is contraindicated in patients with sinus node dysfunction without pacemaker protection, severe atrioventricular block, bilateral bundle branch block, severe congestive heart failure, cardiogenic shock, severe hypotension, and those who are allergic to the drug.

Precautions for children: The safety and effectiveness of this drug in children are not yet known. Precautions for pregnancy and lactation: Pregnant women should use it with caution. It is recommended that lactating women stop using it. Precautions for the elderly: There is no increase in age-related side effects when using this drug in elderly patients. However, elderly patients may experience a drop in blood pressure after taking the drug. In addition, elderly patients are prone to liver and kidney damage, so it should be used with caution. The effective drug dose for elderly patients is lower than normal.

Combination with quinidine can slow down the metabolic process. Combination with local anesthetics increases the occurrence of central nervous system side effects. Propafenone can increase serum digoxin concentrations in a dose-dependent manner. Combination with propranolol and metoprolol can significantly increase their plasma concentrations and elimination half-life, but has no effect on propafenone. Combination with warfarin can increase warfarin blood concentrations and prothrombin time. Combination with cimetidine can increase the steady-state level of propafenone in the blood, but has no effect on its electrophysiological parameters.

Keep in dark place and sealed

50mg

36 months

Yingzi Maishitong (Hebi) Pharmaceutical Co., Ltd.

• Founded in:

  2003-10-09

• Address:

  Haihe Road, Hebi Economic and Technological Development Zone

• Tax NO.:

  914106007538916455

• Registered Funds:

  11.78 million yuan

• Email:

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