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Function and Efficacy

It is a compound antipyretic analgesic. Among them, aminopyrine and phenacetin can inhibit the synthesis and release of prostaglandins in the hypothalamus, restore the normal responsiveness of the receptor neurons in the temperature regulation center, and have an antipyretic effect; at the same time, it also has an analgesic effect by inhibiting the synthesis of prostaglandins. Aminopyrine can also inhibit the synthesis and release of prostaglandins in local inflammatory tissues, stabilize lysosomal enzymes, and affect the phagocytic function of phagocytes to play an anti-inflammatory role. Caffeine is a central nervous system stimulant that can excite the cerebral cortex, increase sensitivity to the outside world, and constrict cerebral blood vessels, thereby enhancing the effect of the first two drugs in relieving headaches. Phenobarbital has sedative, hypnotic, and anticonvulsant effects, which can enhance the analgesic effect of aminopyrine and phenacetin, and prevent convulsions caused by fever.

Ingredients

Each tablet contains 0.125 g of acetaminophen, 0.15 g of aminopyrine, 0.05 g of caffeine, 0.015 g of phenobarbital, and appropriate amounts of auxiliary materials.

Name Description Content CAS NO. Manufacturer
AcetaminophenIngredients

It inhibits the synthesis and release of prostaglandins in the hypothalamus, restores the normal responsiveness of the receptor neurons in the temperature regulation center, and has an antipyretic effect; it has an analgesic effect by inhibiting the synthesis of prostaglandins, etc.

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103-90-2 68

Appearance

This product is white tablets.

Indication

Used for fever and mild to moderate pain.

Usage and Dosage

Take 1-2 tablets at a time, 1-3 times a day, when needed.

Adverse Reactions

Both aminopyrine and phenacetin contained in this compound have obvious adverse reactions. Taking aminopyrine may cause vomiting, rash, fever, heavy sweating and stomatitis, etc. A few cases may cause neutropenia, aplastic anemia, exudative erythema, exfoliative dermatitis, glans erosion, etc. Long-term use of phenacetin can cause renal papillary necrosis, interstitial nephritis and acute renal failure, and may even induce renal pelvic cancer and bladder cancer, and may also cause drug dependence. Phenacetin also easily causes hemoglobin to form methemoglobin, which reduces the oxygen-carrying capacity of the blood and leads to cyanosis. It can also cause hemolysis, liver damage, and has a certain toxicity to the retina.

Precautions

It is contraindicated in patients who are allergic to aminopyrine, phenacetin, caffeine or phenobarbital drugs.

Special Population Medication

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not recommended. Precautions for the elderly: More likely to cause renal damage, so use with caution.

Drug Interactions

Not yet clear.

Storage

Sealed, store in a cool, dry place.

Packaging Specification

Compound

Validity Period

24 months.

Manufacturer

Beijing Shuguang Pharm Co., Ltd.

  • Founded in:

    1979-11-10
  • Address:

    Building 1, No. 7, Lane 1, Xiyuanzi, Dongcheng District, Beijing
  • Tax NO.:

    91110101101524129G
  • Registered Funds:

    12.69 million yuan
  • Website:

  • Email:

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