WYE-125132
1144068-46-1
99%
2026-07-23
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName WYE-125132 Cat No CEI-0106 Description WYE-125132 CAS No 1144068-46-1 Molecular Weight 519.6 Purity >99% Storage 2 years at -20 centigrade Targets mTOR Molecular Formula C27H33N7O4 Solubility No In vitro As an ATP-competitive inhibitor, WYE-125132 can potently inibit mTOR with IC50 of 0.19 nM. And WYE-125132 shows >5,000-fold selective versus PI3Ks. WYE-132 also can inhibit mTORC1 and mTORC2. WYE-132 targeted P-AKT(S473) and AKT function without significantly reducing the steady-state level of P-AKT(T308), which is the PI3K/PDK1 activity biomarker. WYE-132 shows stronger inhibition of cancer cells than that of temsirolimus. WYE-132 can inhibit cell growth and survival, protein synthesis, cell size, bioenergetic metabolism, and adaptation to hypoxia. Treatment of cancer cells with WYE-132 leads to a rapid loss of the phosphorylation at Ser-75. WYE-132-induced Maf1 dephosphorylation correlated with its accumulation in the nucleus and a marked decline in the cellular levels of pre-tRNAs. category Inhibitors(c1514) cas_num 1144068-46-1 Basic Info-
Product Name:
N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea
Other Name:N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea;WYE 125132;WYE 125132(WYE-132);1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyriMidin-6-yl)phenyl)-3-Methylurea;WYE125132/WYE-125132/WYE-132;Urea, N-[4-[1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methyl-;N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea WYE125132(WYE-132);WYE 125132 N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea
CAS No.:1144068-46-1
Molecular Formula:C27H33N7O4
InChIKeys:QLHHRYZMBGPBJG-UHFFFAOYSA-N
Molecular Weight:519.59542
Exact Mass:519.259399
DSSTox ID:DTXSID70649521
Categories:
Characteristics-
PSA:
116
XLogP3:1.27
Density:1.55
Boiling Point:650.2±55.0 °C at 760 mmHg
Flash Point:347.0±31.5 °C
Refractive Index:1.764
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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