A66
1166227-08-2
99%
2026-07-04
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName A66 Cat No CEI-0127 Description A66 can inhibit p110-alpha with IC50 of 32 nM. CAS No 1166227-08-2 Molecular Weight 393.53 Purity >99% Storage 2 years at -20centigrade Powder Targets p110-alpha Molecular Formula C17H23N5O2S2 Chemical Name (2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1,2-dicarboxamide Solubility DMSO 79 mg/mL Water In vitro A66 is a high selective PI3K inhibitor which can inhibit PI3K-alpha with 32 nM. A66 inhibits p110-alpha E545K and p110-alpha H1047R with IC50 of 30 nM and 43 nM. A66 shows strong inhibition to p110-alpha and little inhibition to other PI3K isoform. A66 can inhibit cell lines harboring H1047R mutations in PIK3CA and have high levels of p110-alpha and class-Ia PI3K activity. category Inhibitors(c1514) cas_num 1166227-08-2 Basic Info-
Product Name:
A66
Other Name:CCT128930;(2S)-N1-[2-(tert-Butyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide;(2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1,2-dicarboxamide;(2S)-N1-[2-(tert-Butyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide A 66
CAS No.:1166227-08-2
Molecular Formula:C17H23N5O2S2
InChIKeys:HBPXWEPKNBHKAX-NSHDSACASA-N
Molecular Weight:393.53
Exact Mass:393.129
EC Number:-0
DSSTox ID:DTXSID80655299
HScode:29341000
Categories:
Characteristics-
PSA:
158
XLogP3:2.8
Density:1.354
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product