IRAK inhibitor 1
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CAS No.:
1042224-63-4
Content:
0.98%
Price valid (until):
2026-06-30
Company Type:
Manufactory
Location:
United States
Qualification:
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Description
ProductName IRAK inhibitor 1 Cat No CEI-1373 Description IRAK inhibitor 1 is an inhibitor of interleukin-1 receptor associated kinase 4 (IRAK-4). Product Overview The interleukin-1 receptor associated kinase (IRAK) family is comprised of four family members IRAK-1, IRAK-2, IRAK-3/M, and IRAK-4.Upon activation of their upstream cognate receptors, IRAK-4 is thought to phosphorylate IRAK-1 resulting in the activation and autophosphorylation of IRAK-1 an subsequent phosphorylation of downstream substrates. IRAK inhibitor 1 is an inhibitor of interleukin-1 receptor associated kinase 4 (IRAK-4). CAS No 1042224-63-4 Molecular Weight 293.37 Purity 0.98 Storage Store at -20°C Targets IRAK-4 IC50 35 nM Molecular Formula C17H19N5 Chemical Name 6-imidazo[1,2-a]pyridin-3-yl-N-piperidin-4-ylpyridin-2-amine Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request In vitro The regioisomeric pyridines IRAK inhibitor 1 and it analogue showed contrasting SAR, with the 2,6-pyridine isomer IRAK inhibitor 1 having low-nanomolar potency whilst the 2,4-pyridine isomer 7 showed little activity, despite having a more accessible bidentate-binding motif. At 10 μM, IRAK inhibitor 1 was found to have 39% inhibition for JNK-1 and 15% inhibition for JNK-2, respectivley. category Specialty Chemicals(c26) cas_num 1042224-63-4 Basic Info-
Product Name:
IRAK inhibitor 1
CAS No.:1042224-63-4
Categories:
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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