Ritonavir
155213-67-5
0.985%
2026-07-20
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Ritonavir Cat No CEI-1506 Description Ritonavir is an antiretroviral (HIV) drug and inhibitor ofparticular liver enzyme that normally metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4). Product Overview Ritonavir, previously known as ABT-538, is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) protease that exhibits potent in vitro inhibition against HIV-1 strain as well as HIV-2 strain with 50% effective concentration EC50 values of 0.022 μM and 0.16 μM respectively. Ritonavir binds to the HIV-1 protease inactivating its function to cleave the Gag and Gag-Pol polyproteins into the core proteins and viral enzymes, which results in the formation of noninfectious viral particles. X-ray crystallographic analysis reveals a hydrophobic cluster between the isopropyl substituent on the P3 thiazolyl group of ritonavir and the side chains of Pro-81 and Val-82 of HIV-1 protease within the complex of ritonavir/HIV-1 protease. CAS No 155213-67-5 Molecular Weight 720.9 Purity 0.985 Storage Store at -20°C Synonyms Abbott 84538, ABT-538,Ritonavir Targets HIV protease Molecular Formula C37H48N6O5S2 Chemical Name 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate Solubility Soluble in DMSO > 10 mM Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Inhibitor Drugs(c1439) cas_num 155213-67-5 Basic Info-
Product Name:
Ritonavir
Other Name:2,7,10,12-Tetraazatridecanoic acid,4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-,5-thiazolylmethyl ester,(3S,4S,6S,9S)-;2,4,7,12-Tetraazatridecan-13-oic acid,10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-,5-thiazolylmethyl ester,[5S-(5R*,8R*,10R*,11R*)]-;2,4,7,12-Tetraazatridecan-13-oic acid,10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-,5-thiazolylmethyl ester,(5S,8S,10S,11S)-;ABT 538;Abbott 84538;Ritonavir;A 84538;Norvir;NSC 693184;RTV;Ritomune;Viriton;Ritovir;Empetus;Novir
CAS No.:155213-67-5
Molecular Formula:C37H48N6O5S2
InChIKeys:InChIKey=NCDNCNXCDXHOMX-XGKFQTDJSA-N
Molecular Weight:720.96
Exact Mass:720.94
EC Number:208-127-9
UNII:O3J8G9O825
NSC Number:760369|693184
DSSTox ID:DTXSID1048627
NCI Thesaurus Code:C1609
Color/Form:White to light tan powder
ATC Code:J05AE03|J05AR10|J05AP53|J - Antiinfectives for systemic use
HScode:29341000
Categories:
Characteristics-
PSA:
202
XLogP3:3.9
Appearance:white to beige
Density:1.239±0.06 g/cm3(Predicted)
Melting Point:120-122°C
Boiling Point:947.0±65.0 °C(Predicted)
Flash Point:2℃
Refractive Index:1.600
Water Solubility:Practically insoluble in water;DMSO: soluble 10mg/mL (clear solution, warmed)
Storage Conditions:-20°C Freezer
Vapor Pressure:1.1X10-27 mm Hg @ 25 deg C /Estimated/
Henrys Law Constant:Henry's Law constant = 2.7X10-33 atm-cu m/mol @ 25 °C /Estimated/
Experimental Properties:Hydroxyl radical reaction rate constant = 9.7X10-11 cu cm/molec-sec @ 25 °C /Estimated/
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Eye irritation, Category 2
Carcinogenicity, Category 2
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
H319 Causes serious eye irritation
H351 Suspected of causing cancer
H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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