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Entecavir More Info

1. What is Entecavir?

Entecavir is an oral antiviral medication that is primarily used for the treatment of chronic hepatitis B virus (HBV) infection. It belongs to a class of drugs called nucleoside analogues (specifically, a guanosine nucleoside analogue) and works by inhibiting the replication of the virus in the body.

2. Brand Names:

Entecavir is marketed under several brand names, the most common being:

Baraclude®

3. Mechanism of Action:

Entecavir interferes with the reverse transcription process that the hepatitis B virus uses to reproduce. It works by being incorporated into the viral DNA, which leads to premature termination of the DNA chain. This prevents the virus from multiplying and spreading in the liver.

4. Indications (Uses):

Entecavir is approved for:

Treatment of chronic hepatitis B in adults and children aged 2 years and older who show signs of active viral replication and liver inflammation.

It is typically prescribed for patients who are:

Treatment-naïve (have not received previous HBV treatment)

Resistant to lamivudine (another antiviral drug)

With compensated liver disease (where the liver is still functioning).

It helps to reduce the amount of hepatitis B virus in the body and may improve liver inflammation and fibrosis.

5. Dosage and Administration:

Entecavir must be taken on an empty stomach (at least 2 hours before or after a meal).

Typical adult dosage:

For treatment-naïve patients: 0.5 mg once daily

For patients resistant to lamivudine: 1 mg once daily

Dosages for children are based on weight and are typically adjusted accordingly.

6. Side Effects:

Common side effects may include:

Headache

Fatigue

Dizziness

Nausea

Serious but rare side effects:

Lactic acidosis (buildup of lactic acid in the blood)

Severe liver problems

Exacerbation of hepatitis B after stopping the medication

7. Warnings and Precautions:

Lactic Acidosis and Hepatomegaly with steatosis: Can be life-threatening; characterized by fatigue, abdominal pain, rapid breathing.

Hepatitis B Exacerbation: Stopping Entecavir suddenly may cause a flare-up of hepatitis B.

HIV Co-infection: Entecavir is not effective against HIV and may lead to HIV resistance if used alone in co-infected patients.

Renal Impairment: Dose adjustments are needed for patients with kidney dysfunction.

8. Use in Pregnancy and Breastfeeding:

Classified as Pregnancy Category C in the U.S.

Should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus.

It is unknown whether Entecavir passes into breast milk; breastfeeding is not recommended while taking this medication.

9. Drug Interactions:

Entecavir has minimal drug interactions, but it should be used with caution when taken with other medications that affect kidney function or that are also renally excreted.

10. Resistance:

Resistance to Entecavir can occur, particularly in patients who have previously been treated with lamivudine and have developed resistance to it. Therefore, monitoring HBV DNA levels regularly is important during therapy.

11. Storage:

Store Entecavir at room temperature away from moisture and heat. Keep out of reach of children.

Summary:

Entecavir is a potent antiviral agent effective in suppressing the hepatitis B virus, commonly used as a first-line therapy due to its efficacy and lower risk of drug resistance in naïve patients. It should be used under the supervision of a healthcare provider, and patients should be monitored regularly for response to treatment and potential side effects.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

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For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

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Q5. What HyperChem will provide after shipment?

For sample orders: 
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1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders:
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.