Tylosin Base CAS NO: 1401-69-0

1. Product Name: Tylosin Base (Tylosin A)

2. CAS Number: 1401-69-0

3. Molecular Formula: C₄₆H₇₇NO₁₇

4. Appearance: White to pale yellow crystalline powder.

5. Solubility: Slightly soluble in water; freely soluble in methanol, ethanol, chloroform, ethyl acetate; soluble in dilute acids and bases.

6. Assay (Purity): Typically ≥ 850 µg/mg (85%) to ≥ 950 µg/mg (95%), depending on the supplier and grade (USP/EP/Feed Grade).

7. Packing: Commonly available in:

   • 25 kg fiberboard drums (with inner plastic bag).

   • 20 kg cartons.

   • 1 kg, 5 kg aluminum foil bags inside cartons (for smaller quantities, often for research).

   • Custom packaging may be available from some suppliers.

8. Storage: Store in a tightly sealed container, protected from light and moisture, at room temperature (typically 2-8°C or as specified by the supplier for long-term stability).

9. Shelf Life: Usually 24-36 months from the date of manufacture when stored properly.

10. Application/Primary Use:

    • Veterinary Antibiotic: Tylosin Base is the active pharmaceutical ingredient (API) primarily used in the formulation of veterinary medicines.

    • Indications: Used to treat and prevent bacterial infections caused by Gram-positive bacteria and certain Gram-negative bacteria (like Campylobacter), Mycoplasma, and Spirochetes in animals.

    • Target Species: Mainly used in poultry (chickens, turkeys), swine (pigs), and bees. Also used in cattle, sheep, and fish in some regions/formulations.

    • Common Conditions Treated:

      • Poultry: Chronic Respiratory Disease (CRD - caused by Mycoplasma gallisepticum), Infectious Sinusitis (in turkeys), Necrotic Enteritis.

      • Swine: Swine Dysentery (caused by Brachyspira hyodysenteriae), Porcine Proliferative Enteropathy (PPE/Ileitis - caused by Lawsonia intracellularis), Porcine Respiratory Disease Complex (PRDC), Arthritis.

      • Bees: European Foulbrood (caused by Melissococcus plutonius).

    • Growth Promoter: Historically used as a feed additive at sub-therapeutic levels to promote growth and improve feed efficiency in livestock (though this use is increasingly restricted or banned in many regions due to antibiotic resistance concerns).

    • Research: Used in laboratory research related to microbiology and antibiotic mechanisms.

11. Important Notes:

    • Not for Human Use: Tylosin is approved for veterinary use only.

    • Formulation: Tylosin Base is insoluble in water. It is typically formulated as soluble powders (using salts like Tylosin Tartrate or Tylosin Phosphate), premixes, injectables, or tablets/pellets for oral administration.

    • Regulations: Usage is subject to veterinary prescription and regulations regarding withdrawal periods before slaughter vary significantly by country and product formulation.

Summary:

• CAS: 1401-69-0

• Packing: Typically 25kg drums, 20kg cartons, or smaller bags (1kg, 5kg) for research.

• Application: Veterinary antibiotic API for treating bacterial infections (especially respiratory and enteric) and Mycoplasma in poultry, swine, and bees. Also used in other livestock and historically as a growth promoter (now restricted). Requires formulation into usable products (soluble salts, premixes, injectables).