99% High Quality Elamipretide 736992-21-5

Elamipretide More Info

Elamipretide, identified by the CAS registry number 736992-21-5, is a novel, synthetic tetrapeptide with the sequence D-Arg-dimethylTyr-Lys-Phe-NH2. It is a water-soluble, cationic molecule specifically designed to target the inner mitochondrial membrane. Its development represents a significant advancement in the field of mitochondrial medicine, stemming from extensive research into the role of mitochondrial dysfunction in various diseases. The compound was rationally engineered to concentrate in mitochondria and interact with cardiolipin, a phospholipid crucial for maintaining the structure and function of the mitochondrial electron transport chain. This targeted mechanism of action distinguishes it from broader-acting antioxidants and positions it as a potential disease-modifying therapeutic agent.

Primary Uses and Applications

Elamipretide is exclusively developed for therapeutic applications, specifically for the treatment of rare genetic disorders characterized by primary mitochondrial dysfunction. Its primary investigational uses have been in conditions such as Barth syndrome, a rare genetic disorder affecting the heart and muscles, and primary mitochondrial myopathy (PMM). Its mechanism involves stabilizing the structure of the mitochondrial cristae, improving electron transport chain efficiency, and reducing excessive production of reactive oxygen species (ROS). By addressing these fundamental aspects of mitochondrial failure, it aims to improve cellular energy production and restore function in affected tissues, particularly those with high energy demands like the heart, skeletal muscle, and nervous system.

Application Market

The market for Elamipretide is highly specialized and falls within the niche orphan drug and rare disease therapeutics sector. Its development and commercialization are targeted at addressing severe unmet medical needs in small patient populations, a market segment often supported by orphan drug designation from regulatory bodies like the FDA and EMA. This status provides incentives such as market exclusivity periods. The commercial landscape is dominated by the biopharmaceutical company that holds the development rights, steering it through clinical trials and the regulatory approval process. The economic model is typical of orphan drugs, focusing on high-value, specialized distribution channels to hospitals and treatment centers managing these rare conditions, rather than a broad, general pharmaceutical market.

Handling and Regulatory Considerations

As an investigational pharmaceutical ingredient, elamipretide is handled under strict controlled conditions according to current Good Manufacturing Practice (cGMP) guidelines. It is not a bulk industrial chemical and is formulated into a final drug product under sterile conditions for parenteral administration, typically intravenous infusion. All handling is conducted by trained professionals within clinical or manufacturing settings. Its use is strictly confined to controlled clinical trials or, upon approval, prescribed by physicians for its designated indications. Regulatory oversight is comprehensive, governed by health authorities like the U.S. FDA, which approve its use based on rigorous review of clinical trial data demonstrating safety and efficacy for specific patient populations.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.