99% Best Quality Avanafil API

Avanafil More Info

Avanafil is a potent and selective orally administered inhibitor of phosphodiesterase type 5 (PDE5), developed as a second-generation treatment for erectile dysfunction. It was designed to improve upon the pharmacokinetic profile of earlier PDE5 inhibitors, specifically aiming for a faster onset of action and greater selectivity for the PDE5 enzyme over other phosphodiesterases. This heightened selectivity is intended to reduce the risk of off-target side effects associated with inhibition of other PDE enzymes, such as PDE6 in the retina. Its chemical structure is a result of targeted molecular optimization to enhance binding affinity and specificity for the PDE5 active site, resulting in a rapid dissociation constant that contributes to its quick pharmacological effect.

Uses and Applications

The primary and approved medical application of Avanafil is for the treatment of erectile dysfunction (ED) in adult men. It facilitates erectile function by enhancing the effects of nitric oxide, which mediates the relaxation of smooth muscle in the corpus cavernosum of the penis and increases blood flow following sexual stimulation. Its key distinguishing clinical feature is its rapid onset of action, with studies showing efficacy within 15 minutes for some patients. It is formulated exclusively for oral administration in fixed-dose tablets. Beyond its primary use, it is also the subject of ongoing research for potential applications in other conditions where PDE5 inhibition may be beneficial, such as pulmonary arterial hypertension.

Application Market

The market for Avanafil operates within the highly competitive erectile dysfunction pharmaceutical sector, which is dominated by well-established first-generation products. It is positioned as a premium product, leveraging its rapid onset and improved selectivity profile to target a specific segment of consumers seeking these advantages. The market is global, with availability primarily through prescription in most regions, though regulatory status may vary. Following patent expiration of earlier agents, the ED market includes both branded and generic products; however, Avanafil itself remains a branded product under names like Stendra® and Spedra®, with distribution channels primarily involving retail and online pharmacies serving patients who have obtained a prescription.

Important Considerations

Avanafil is a prescription medication with important safety considerations. It is contraindicated in patients taking any form of organic nitrates (e.g., nitroglycerin) due to the risk of a severe, potentially fatal drop in blood pressure. Other important contraindications include patients with a history of certain cardiovascular conditions. Common adverse effects include headache, flushing, nasal congestion, and back pain. In an industrial setting, handling the pure active pharmaceutical ingredient requires the use of appropriate personal protective equipment (PPE) and engineering controls to prevent occupational exposure through inhalation or skin contact. It is for use only in finished, prescribed dosage forms and must be used under the guidance of a healthcare professional who can assess cardiovascular fitness for sexual activity.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.