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API Metformin HCl

Name: API Metformin HCl
Brand: Hyper Chem
Price: 250 USD
Availability: InStock

14 Inquiries

Unit Price: Get Latest Price 

CAS No.:

1115-70-4

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum 25kg/Drum

Price valid (until):

2025-12-07

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Metformin HCl
CAS number	1115-70-4
Description	Metformin is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. Metformin exerts an anorexiant effect, decreasing caloric intake. Metformin decreases gluconeogenesis (glucose production) in the liver. Metformin inhibits basal secretion from the pituitary gland of growth hormone, adrenocorticotropic hormone, follicle stimulating hormone, and expression of proopiomelanocortin, which in part accounts for its insulin-sensitizing effect with multiple actions on tissues including the liver, skeletal muscle, endothelium, adipose tissue, and the ovaries.
Appearance	Solid powder
Related CAS	1115-70-4 (HCl) 657-24-9 (free base) 121369-64-0 (glycinate) 34461-22-8 ( embonate) 58840-24-7 (orotate) 1384526-74-2 (icosapent)
Synonym	Metformin Hydrochloride; ADX-155; EFB-0027; EX-404; La-6023; SMP-862; ADX 155; EFB 0027; EX 404; La 6023; SMP 862; ADX155; EFB0027; EX404; La6023; SMP862; Fortamet
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Metformin HCl More Info

Metformin HCl (Metformin Hydrochloride) is a first-line oral antidiabetic agent for type 2 diabetes mellitus, with a well-established safety and efficacy profile.

Core Indications

Primary treatment of type 2 diabetes to improve glycemic control in adults and children (≥10 years old).

Prevention of type 2 diabetes in individuals with prediabetes (impaired glucose tolerance or fasting glucose).

Management of polycystic ovary syndrome (PCOS) to improve insulin resistance and regulate menstrual cycles.

Mechanism of Action

Reduces hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis.

Improves insulin sensitivity in peripheral tissues (muscle and adipose tissue), enhancing glucose uptake.

Decreases intestinal absorption of glucose, without stimulating insulin secretion from pancreatic β-cells.

Key Usage & Dosage

Usual adult starting dose: 500 mg once or twice daily with meals (to minimize gastrointestinal side effects).

Titration: Gradually increase to 1000–2000 mg daily (maximum 2550 mg/day), divided into 2–3 doses.

Extended-release formulations: 500–1000 mg once daily with the evening meal, titrated as needed.

Renal function adjustment: Contraindicated if eGFR < 30 mL/min/1.73m²; dosage reduction required for eGFR 30–45 mL/min/1.73m².

Safety Precautions

Contraindicated in severe renal impairment, acute liver disease, severe infection, hypoxia, or metabolic acidosis (including lactic acidosis).

Common side effects: Gastrointestinal disturbances (nausea, diarrhea, abdominal pain) – usually transient with dose titration.

Rare but serious risk: Lactic acidosis (symptoms include weakness, myalgia, dyspnea, abdominal pain) – discontinue and seek emergency care if suspected.

Avoid excessive alcohol intake, as it increases lactic acidosis risk.

Monitor renal function, fasting blood glucose, and HbA1c regularly during treatment.

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Basic Info

Product Name:

Metformin hydrochloride

Other Name:

Imidodicarbonimidic diamide,N,N-dimethyl-,hydrochloride (1:1);Biguanide,1,1-dimethyl-,monohydrochloride;Imidodicarbonimidic diamide,N,N-dimethyl-,monohydrochloride;Biguanide,1,1-dimethyl-,hydrochloride;Metformin hydrochloride;N,N-Dimethylbiguanide hydrochloride;1,1-Dimethylbiguanide hydrochloride;Meguan;N1,N1-Dimethylbiguanide hydrochloride;Diabefagos;Glucophage;Glyformin;LA 6023;Dabex;Denkaform;Dextin;Diabetmin;Diabex;Apophage;Benofomin;Diformin Retard;Dimefor;Fornidd;Geamet;Glucaminol;Glucofago;Glucomet;Glucomine;Glucoform;Glucomin;Gluconil;Glucophage 850;Glucophage Forte;Glucophage-Mite;Glucophage Retard;Gludepatic;Glufor;Gluformin;Glumeformin;Glumin;Glupermin;Glyciphage;Glycon;Metforal;Metomin;Miformin;Orabet;Siamformet;Walaphage;Diaformin;Diformin;Glyceriphage;Diabetosan;Dialon;Glucophage XR;N,N-Dimethylbiguanidinium chloride;Apo-Metformin;Brot;Glumetza;Glifage;Glucophage SR;Melbin;N,N-Dimethylbiguanidine monohydrochloride;Glucoformin;Riomet;Glumin XR;Metgluco;Neodipa;Diabetmim;FORTAMET;Obimat-SR;15537-72-1;56258-19-6;144377-16-2

CAS No.:

1115-70-4

Molecular Formula:

C4H11N5.ClH

InChIKeys:

InChIKey=OETHQSJEHLVLGH-UHFFFAOYSA-N

Molecular Weight:

165.62500

Exact Mass:

165.07800

EC Number:

605-006-2

HScode:

2925290090

Categories:

Hormones and the Endocrine System

Characteristics

PSA:

88.99000

XLogP3:

1.05850

Appearance:

crystalline solid

Melting Point:

232 °C

Boiling Point:

224.1ºC at 760 mmHg

Flash Point:

89.3ºC

Water Solubility:

In water, 1.06X10+6 mg/L (miscible) at 25 deg C (est)

Storage Conditions:

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature 2 - 8 deg C. Storage class (TRGS 510): Non Combustible Solids. /Metformin hydrochloride/

Vapor Pressure:

0.0929mmHg at 25°C

See More Metformin hydrochloride Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature 2 - 8 deg C. Storage class (TRGS 510): Non Combustible Solids. Metformin hydrochloride

See More Metformin hydrochloride Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

14 Inquiries

Country	Product	Purchase Quantity	Date Posted
Vietnam	1115-70-4 Metformin hydrochloride high quality 99.9%	5 G	Aug 27, 2023
Singapore	Metformin HCL 99% pharmaceutical API powder CAS 1115-70-4 Metformin hydrochloride	1000 KG	Oct 5, 2023
Pakistan	Metformin HCL 99% pharmaceutical API powder CAS 1115-70-4 Metformin hydrochloride	250 KG	May 24, 2023
United Kingdom	Metformin	1 KG	Sep 25, 2025
United Kingdom	Metformin HCL powder Stock	1 KG	Sep 26, 2025
Singapore	Metformin API	1000 KG	Oct 5, 2023
Bangladesh	Metformin HCL BP	40.00 MT	Nov 10, 2023
Pakistan	Metformin Hydrochloride	500 KG	Oct 13, 2025
India	Metformin HCl	17 MT	Jul 25, 2025
Pakistan	Metformin Hydrochloride	3000 KG	Jun 20, 2025
Bangladesh	Metformin HCL BP (As ApI)	40 MT	Nov 24, 2023
China	Metformin HCL	1 KG	Oct 13, 2023
Singapore	Metformin API	100 KG	Oct 5, 2023
Singapore	Pharmaceutical Intermediate cas 50-56-6 Metformin hydrochloride peptide Organic Chemicals 99% Fine powders HHD Wuhan hhd	100 KG	Oct 5, 2023

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